MedInTO Medicine and Surgery

Research products

All my research products

Selected research products

An Overview of the Molecular Cues and Their Intracellular Signaling Shared by Cancer and the Nervous System: From Neurotransmitters to Synaptic Proteins, Anatomy of an All-Inclusive Cooperation
2022-01-01 Arese, Marco; Bussolino, Federico; Pergolizzi, Margherita; Bizzozero, Laura https://iris.unito.it/handle/2318/1881270

Tumoral Neuroligin 1 Promotes Cancer–Nerve Interactions and Synergizes with the Glial Cell Line-Derived Neurotrophic Factor
2022-01-01 Bizzozero, Laura; Pergolizzi, Margherita; Pascal, Davide; Maldi, Elena; Villari, Giulia; Erriquez, Jessica; Volante, Marco; Serini, Guido; Marchiò, Caterina; Bussolino, Federico; Arese, Marco https://iris.unito.it/handle/2318/1835781

The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway
2022-01-01 Pergolizzi M, Bizzozero L, Maione F, Maldi E, Isella C, Macagno M, Mariella E, Bardelli A, Medico E, Marchio Caterina, Serini G, Di Nicolantonio F, Bussolino F, Arese M https://iris.unito.it/handle/2318/1873519

LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion
2021-01-01 Camillo, Chiara; Facchinello, Nicola; Villari, Giulia; Mana, Giulia; Gioelli, Noemi; Sandri, Chiara; Astone, Matteo; Tortarolo, Dora; Clapero, Fabiana; Gays, Dafne; Oberkersch, Roxana E; Arese, Marco; Tamagnone, Luca; Valdembri, Donatella; Santoro, Massimo M; Serini, Guido https://iris.unito.it/handle/2318/1806736

Role of TGFβ1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells
2021-01-01 Gualandris A, Noghero A, Corà D, Astanina E, Arese M, Bussolino F https://iris.unito.it/handle/2318/1870487

Vittorio Badini Confalonieri, Liberali piemontesi e altri profili, a cura di Luca Badini Confalonieri
2020-01-01 Luca Badini Confalonieri https://iris.unito.it/handle/2318/1725496

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib.
2019-01-01 Amatu A, Schirripa M, Tosi F, Lonardi S, Bencardino K, Bonazzina E, Palmeri L, Patanè DA, Pizzutilo EG, Mussolin B, Bergamo F, Alberti G, Intini R, Procaccio L, Arese M, Marsoni S, Nichelatti M, Zagonel V, Siena S, Bardelli A, Loupakis F, Di Nicolantonio F, Sartore-Bianchi A, Barault L https://iris.unito.it/handle/2318/1712864

Tumor progression: the neuronal input
2018-01-01 Arese, Marco; Bussolino, Federico; Pergolizzi, Margherita; Bizzozero, Laura; Pascal, Davide https://iris.unito.it/handle/2318/1670744

Modulation of Angiopoietin 2 release from endothelial cells and angiogenesis by the synaptic protein Neuroligin 2
2018-01-01 Pergolizzi, Margherita; Bizzozero, Laura; Riccitelli, Elena; Pascal, Davide; Samarelli, Anna Valeria; Bussolino, Federico; Arese, Marco https://iris.unito.it/handle/2318/1670745

Neuroligin 1 induces blood vessel maturation by cooperating with the α6 integrin.
2014-01-01 Samarelli AV;Riccitelli E;Bizzozero L;Silveira TN;Seano G;Pergolizzi M;Vitagliano G;Cascone I;Carpentier G;Bottos A;Primo L;Bussolino F;Arese M https://iris.unito.it/handle/2318/148383

A peptide from the extracellular region of the synaptic protein α Neurexin stimulates angiogenesis and the vascular specific tyrosine kinase Tie2
2013-01-01 S. Graziano; S. Marchiò; F. Bussolino; M. Arese https://iris.unito.it/handle/2318/127094

Differential regulation of neurexin at glutamatergic and GABAergic synapses.
2013-01-01 Pregno G; Frola E; Graziano S; Patrizi A; Bussolino F; Arese M; Sassoè-Pognetto M. https://iris.unito.it/handle/2318/135208

The synaptic proteins &[beta]-Neurexin and Neuroligin synergize withECM-binding VEGFA during zebrafish vascular development
2012-01-01 Rissone A; Foglia E; Sangiorgio L; Nicoli S; Cimbro S; Beltramo M; Bussolino F; Cotelli F; Arese M https://iris.unito.it/handle/2318/100432

IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism.
2012-01-01 Napione L; Strasly M; Meda C; Mitola S; Alvaro M; Doronzo G; Marchiò S; Giraudo E; Primo L; Arese M; Bussolino F. https://iris.unito.it/handle/2318/119110

Neurexins and neuroligins: synapses look out of the nervous system.
2011-01-01 Bottos A; Rissone A; Bussolino F; Arese M. https://iris.unito.it/handle/2318/91437

Mature endothelium and neurons are simultaneously derived from embryonic stem cells by 2D in vitro culture system
2011-01-01 Noghero A; Arese M; Bussolino F; Gualandris A https://iris.unito.it/handle/2318/79957

Nervous vascular parallels: axon guidance and beyond
2011-01-01 M. Arese; G. Serini; F. Bussolino https://iris.unito.it/handle/2318/90091

Characterization of the Neuroligin gene family expression and evolution in zebrafish
2010-01-01 Rissone A; Sangiorgio L; Monopoli M; Beltrame M; https://iris.unito.it/handle/2318/67071

The synaptic proteins Neurexins and Neuroligins are widely expressed in the vascular system and contribute to its functions
2009-01-01 Bottos A; Destro E; Rissone A; Graziano S; Cordara ; Assenzio B; Cera MR ; Mascia L; Bussolino F; Arese M https://iris.unito.it/handle/2318/60623

Microenvironment drives the endothelial or neural fate of differentiating embryonic stem cells coexpressing neuropilin-1 and Flk-1
2009-01-01 A. Gualandris; A. Noghero; M. Geuna; M. Arese; D. Valdembri; G. Serini; F. Bussolino https://iris.unito.it/handle/2318/44722

Besides adhesion: new perspectives of integrin functions in angiogenesis
2008-01-01 G. Serini; L. Napione; M. Arese; F. Bussolino https://iris.unito.it/handle/2318/40241

Comparative genome analysis of the neurexin gene family in Danio rerio: insights into their functions and evolution
2007-01-01 RISSONE A; MONOPOLI M; BELTRAME M; BUSSOLINO F; COTELLI F; ARESE M https://iris.unito.it/handle/2318/42138

Gene expression profiling of HMGB1-stimulated endothelial cells: a balancing act between angiogenesis and inflammation
2006-01-01 FABRIZIO MANIERO; ERIKA DESTRO; MAURO PATRONE; MARCO PEDRAZZI; MARIO PASSALACQUA; FEDERICO BUSSOLINO; MARCO ARESE https://iris.unito.it/handle/2318/19691

Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1
2006-01-01 MITOLA S; BRENCHIO B; PICCININI M; TERTOOLEN L; ZAMMATARO L; BREIER G; RINAUDO MT; DEN HERTOG J; ARESE M; BUSSOLINO F https://iris.unito.it/handle/2318/40096

CCL16 activates an angiogenic program in vascular endothelial cells
2004-01-01 Strasly M; Doronzo G; Cappello P; Valdembri D; Arese M; Mitola S; Moore P; Alessandri G; Giovarelli M; Bussolino F. https://iris.unito.it/handle/2318/38756

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells
2004-01-01 AUDERO E; CASCONE I; MANIERO F; NAPIONE L; ARESE M; LANFRANCONE L; BUSSOLINO F https://iris.unito.it/handle/2318/40583

Biological aspects of tumour angiogenesis
2003-01-01 F. BUSSOLINO; ARESE M; AUDERO E; GIRAUDO E; MARCHIÒ S; MITOLA S; PRIMO L; SERINI G https://iris.unito.it/handle/2318/11441

Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat.
2001-01-01 L. DEL SORBO; M. ARESE; E. GIRAUDO; M. TIZZANI; L. BIANCONE; F. BUSSOLINO; G. CAMUSSI https://iris.unito.it/handle/2318/36358

HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment.
2001-01-01 ARESE M ;FERRANDI C ;PRIMO L ;CAMUSSI G ;BUSSOLINO F https://iris.unito.it/handle/2318/40290

The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium.
2000-01-01 GUALANDRIS A ;ANNES JP ;ARESE M ;NOGUERA I ;JURUKOVSKI V ;RIFKIN DB https://iris.unito.it/handle/2318/31014

Modulation of cell growth and transformation by doxycycline-regulated FGF-2 expression in NIH-3T3 cells.
1999-01-01 GUALANDRIS A ;ARESE M ;SHEN B ;RIFKIN DB https://iris.unito.it/handle/2318/31185

Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis.
1999-01-01 CALLEA L; M. ARESE; ORLANDINI A; BARGNANI C; PRIORI A; BUSSOLINO F. https://iris.unito.it/handle/2318/37512

Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals
1999-01-01 M. ARESE; CHEN Y; FLORKIEWICZ RZ; GUALANDRIS A; SHEN B; RIFKIN DB https://iris.unito.it/handle/2318/9504

Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107.
1998-01-01 SHEN B ;ARESE M ;GUALANDRIS A ;RIFKIN DB https://iris.unito.it/handle/2318/31149

Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha.
1997-01-01 Montrucchio G; Lupia E; de Martino A; Battaglia E; Arese M; Tizzani A;F. Bussolino; G. Camussi. https://iris.unito.it/handle/2318/46450

Platelet-activating factor and angiogenesis.
1996-01-01 G. Camussi; Montrucchio G; Lupia E; Arese M; F. Bussolino. https://iris.unito.it/handle/2318/45170

Correlation between nitric oxide synthase activity and reduced glutathione level in human and murine endothelial cells
1996-01-01 GHIGO D; GEROMIN D; FRANCHINO C; TODDE R; PRIOTTO C; COSTAMAGNA C; ARESE M; GARBARINO G; PESCARMONA GP; BOSIA A https://iris.unito.it/handle/2318/39150

Anti-tumor activity of cytokines against opportunistic vascular tumors in mice.
1996-01-01 Dong QG; Graziani A; Garlanda C; De Calmanovici RW; Arese M; Soldi R; Vecchi A; Mantovani A; F. Bussolino https://iris.unito.it/handle/2318/45118

Removal of constitutive and inducible nitric oxide synthase-active compounds in a modified hemodiafiltration with on-line production of substitution fluid: the contribution of convection and diffusion.
1996-01-01 Arese M; Cristol JP; Bosc JY; F. Bussolino; Wratten ML; Tetta C; Strasly M; Canaud B. https://iris.unito.it/handle/2318/46795

IL-6 is an in vitro and in vivo autocrine growth factor for middle T antigen-transformed endothelial cells.
1996-01-01 GIRAUDO E; M. ARESE; TONIATTI C; STRASLY M; PRIMO L; MANTOVANI A; CILIBERTO G; BUSSOLINO F. https://iris.unito.it/handle/2318/37889

Microvessel count is predictive of patients' survival in laryngeal squamous-cell carcinoma.
1996-01-01 BEATRICE F ;GIUSTI U ;BISCIARI T ;CAMMAROTA R ;NAVONE R ;PALESTRO G ;RAGONA R ;SARTORIS A ;ARESE M ;BUSSOLINO F ;VALENTE G https://iris.unito.it/handle/2318/31188

Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.
1995-01-01 F. Bussolino; Arese M; Montrucchio G; Barra L; Primo L; Benelli R; F . Sanavio;M. Aglietta; D. Ghigo; Rola-Pleszczynski MR; A.Bosia; A. Albini; G. Camussi https://iris.unito.it/handle/2318/43913

Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase.
1995-01-01 D. Ghigo; Arese M; Todde R; Vecchi A; Silvagno F; Costamagna C; Dong QG; Alessio M; Heller R; Soldi R; Trucco F; Garbarino G; Pescarmona G; Mantovani A; F. Bussolino; A. Bosia https://iris.unito.it/handle/2318/46615

La rigenerazione endoteliale
1995-01-01 Bussolino F; Arese M; Primo L; Resi L; Tanganelli P; Weber G https://iris.unito.it/handle/2318/123091

Platelet-activating factor production by human fetal microglia. Effect of lipopolysaccharides and tumor necrosis factor-alpha.
1995-01-01 Jaranowska A;Bussolino F;Sogos V;Arese M;Lauro GM;Gremo F https://iris.unito.it/handle/2318/115492

In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis.
1995-01-01 Silvagno F; Follenzi A; Arese M; Prat M; Giraudo E; Gaudino G; G. Camussi; Comoglio PM; F. Bussolino https://iris.unito.it/handle/2318/46264

Enhanced production of nitric oxide by blood-dialysis membrane interaction.
1995-01-01 AMORE A; BONAUDO R; D. GHIGO; ARESE M; COSTAMAGNA C; CIRINA P; GIANOGLIO B; PERUGINI L; COPPO R https://iris.unito.it/handle/2318/42179

Multiple roles of platelet-activating factor in the nervous system.
1995-01-01 F. Bussolino ; Soldi R;M. Arese ; Jaranowska A; Sogos V; Gremo F. https://iris.unito.it/handle/2318/46129

Platelet-activating factor directly stimulates in vitro migration of endothelial cells and promotes in vivo angiogenesis by a heparin-dependent mechanism.
1995-01-01 G. Camussi; Montrucchio G; Lupia E; De Martino A; Perona L; Arese M; Vercellone A; Toniolo A; F. Bussolino. https://iris.unito.it/handle/2318/116238

Regulation of nitric oxide synthesis in uraemia.
1995-01-01 Arese M; Strasly M; Ruva C; Costamagna C; D. Ghigo; MacAllister R; Verzetti G; Tetta C; A. Bosia; F. Bussolino. https://iris.unito.it/handle/2318/46451

Actions of molecules which regulate hemopoiesis on endothelial cells: memoirs of common ancestors?
1994-01-01 F. Bussolino; Bocchietto E; Silvagno F; Soldi R; Arese M; Mantovani A. https://iris.unito.it/handle/2318/45718

Human endothelial cells are targets for platelet-activating factor (PAF).Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF.
1994-01-01 F. Bussolino; Silvagno F; Garbarino G; Costamagna C; Sanavio F; Arese M; Soldi R; M. Aglietta; Pescarmona G; G. Camussi; A. Bosia https://iris.unito.it/handle/2318/44151

Involvement of a serine protease in the synthesis of platelet-activating factor by endothelial cells stimulated by tumor necrosis factor-alpha or interleukin-1 alpha.
1994-01-01 F. Bussolino; Arese M; Silvestro L; Soldi R; Benfenati E; Sanavio F; Aglietta M; A. Bosia; G. Camussi https://iris.unito.it/handle/2318/46570

 

 

Courses

• ADE - INTRODUCTION TO MEDICAL BIOCHEMISTRY (SCB0309)
  MedInTO Medicine and Surgery
• Basi biochimico-molecolari del metabolismo (MSL0410)
  Laurea magistrale in Medicina e Chirurgia San Luigi Gonzaga
• Biochemical and Molecular Basis of Metabolism (SCB0314)
  MedInTO Medicine and Surgery
• Biochemical and Molecular Basis of Metabolism - Module of Biochemistry (SCB0314C)
  MedInTO Medicine and Surgery
• Biochimica (MSL0426G)
  Laurea magistrale in Medicina e Chirurgia San Luigi Gonzaga
• Exploiting neuronal biology to fight tumor progression. Instructor prof Marco Arese
  Programma MD-PhD della Scuola di Medicina
• Preparatory Biochemistry (SCB0313)
  MedInTO Medicine and Surgery
• Scienze psichiatriche (SCB0063)
  Laurea magistrale in Medicina e Chirurgia San Luigi Gonzaga

Research topics

Research main topics

 

• I dedicated my early scientific work to various mediators involved in vascular biology. During my experience abroad (New York) I worked on the cellular transforming role of intranuclear forms of FGF-2.

• Upon returning to Italy I devoted myself to the study of the extra-neuronal functions of two synaptic proteins, Neurexin and Neuroligin, originally isolated from the synapses of the central nervous system. I provided the first evidence that these proteins are expressed by endothelial and smooth muscle cells and modulate physiological angiogenesis  

• In the last ten years I studied the role of Neuroligin as a tumor-produced protein and its role in the progression of Colorectal cancer (CRC). When discovered at the metastatic stage, CRC is still incurable. Despite recent improvements in precision treatment for this disease, new molecular targets and prognostic/predictive indicators are highly needed. At the synapse, Neuroligin interacts with the tumor suppressor adenomatous polyposis Coli (APC), which in turn is highly involved in the development of CRC and is a major player in the WNT/beta-catenin pathway. Neuroligin  is expressed in human CRC, including clusters of aggressive migratory (budding) single tumor cells and vascular emboli. Moreover Neuroligin induces cancer cells intra/extravasation and in vivo metastatization. Our goal now is to investigate the mechanistic involvement of Neuroligin in the WNT pathway and in  the promotion of CRC cell metastatization, as well as its synergy/antagonism with anti-WNT drugs, in the hope to obtain future therapeutic leads.

 

 

 

Academic bodies

• Department Council - Department of Oncology

• Consiglio di Dipartimento - Dipartimento di Oncologia

Office hours

Tutti i giorni previo appuntamento telefonico allo 011-9933846, email: marco.arese@unito.it