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Basic pathology and immunology - Module of Immunology

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Basic pathology and immunology - Module of immunology

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Academic year 2023/2024

Course ID
SCB0205B
Teachers
Federica Cavallo
Laura Conti
Year
2nd year
Teaching period
First semester
Type
Basic
Credits/Recognition
4 (32 hours of lectures, 16 hours of exercises)
Course disciplinary sector (SSD)
MED/04 - experimental medicine and pathophysiology
Delivery
Lecture
Language
English
Attendance
Mandatory
Type of examination
Written
Type of learning unit
modulo
Modular course
Basic Pathology and Immunology (SCB0205)
Prerequisites
Having a solid background on the basis of genetics and molecular/cellular biology from previous courses
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Sommario del corso

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Course objectives

An understanding of the immune system is central to the understanding of how the body interacts with its surroundings, and how it both protects itself and responds to infectious disease. The course leads the student through both innate and adaptive immunity, how infection is detected, and how the cells of the immune system interact to generate a response. The mechanisms underlying allergy and hypersensitivity and the immune response to tumors are also provided. 


BASIC IMMUNOLOGY MODULE:

The students must register on the Moodle course Basic Immunology at 

https://biotec.i-learn.unito.it/course/view.php?id=1094

The lectures and "learning insights" will be made available on that site.


 

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Results of learning outcomes

Understanding of the essential aspects of immunity required to understand immunological diseases, investigations and treatment.

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Program

  • Overview of the immune system
  • The natural immune response. The pattern recognition receptors and their ligands.
  • The cytokine network.
  • The complement system: activation and effector functions
  • The Major Histocompatibility Complex: genomic organization and polimorfisms. Antigen presentation to T cells.
  • Cells of the adaptive immune response.
  • The T cell receptor. Thymic education and antigen recognition by T cells. T cell activation and effector mechanisms.
  • B cells. The generation of antibodies diversity. T and B cell cooperation. Antibody production. AID and its role in class switching and somatic hypermutation. Molecular structure and effector functions of antibodies.
  • Functional anatomy of the immune system
  • Self-tolerance and tolerance induction to exogenous antigens.
  • Hypersensitivity and Autoimmunity.
  • Basic concepts in tumor immunology and immunotherapy.
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Course delivery

The course mainly consists of lectures associated with exercise activities.

Exercises (multiple-choice, true-false, and matching questions; immunology-based problems and case studies) will be proposed to the students to test their understanding of the topic covered during the lectures. In addition, some "Learning insights" will be proposed on Vaccines, Autoimmunity, Immunodeficiency, and Tumor Immunology.


BASIC IMMUNOLOGY MODULE:

The students must register on the Moodle course Basic Immunology at 

https://biotec.i-learn.unito.it/course/view.php?id=1094

The lectures and "learning insights" will be made available on that site.


 

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Learning assessment methods

Written test (in presence, through the Moodle platform). It will last 27 minutes and include 33 (multiple-choice, true/false, matching) questions. For each correctly answered question, +1; for blank or incorrectly answered questions, 0. A total score of >30.5 points will correspond to 30 cum laude. 

 

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Support activities

For those that show gross deficiencies in the prerequisites, support is offered individually or in small groups outside lesson. Updated reviews (mainly from Nature Reviews Immunology) on topics covered in class will be provided for those students that want to deepen their knowledge in the field.

Suggested readings and bibliography

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  • Janeway's Immunobiology, Ninth edition, K Murphy, Garland Science;
  • The Immune System, Fourth Edition, P Parham, Garland Science.


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Notes

For the BASIC IMMUNOLOGY MODULE only: The students must register on the Moodle course Basic Immunology at https://biotec.i-learn.unito.it/course/view.php?id=1094

The slides presented during the lectures and the "learning insights", and the exercises will be made available on that site.


Students with DSA or disabilities are kindly requested to take note of the reception services and support services offered by the University of Turin, and in particular of the procedures required for exam support.

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Last update: 29/11/2023 14:17
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