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Basic pathology and immunology - Module of General pathology
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Basic pathology and immunology - Module of General pathology
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Academic year 2024/2025
- Course ID
- SCB0205A
- Teachers
- Gabriella Marisa Leonarduzzi (Lecturer)
Paola Francesca Gamba (Lecturer) - Year
- 2nd year
- Teaching period
- First semester
- Type
- Basic
- Credits/Recognition
- 6 (48 hours of lectures, 24 hours of exercises)
- Course disciplinary sector (SSD)
- MED/04 - experimental medicine and pathophysiology
- Delivery
- E-learning
- Language
- English
- Attendance
- Mandatory
- Type of examination
- Oral
- Type of learning unit
- modulo
- Modular course
- Basic Pathology and Immunology (SCB0205)
- Prerequisites
- Basic knowledge of cell biology, histology and anatomy in order to understand the causes and the mechanisms of damage.
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Sommario del corso
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Course objectives
General Pathology objectives: this part of the course will provide molecular basis for understanding causes, mechanisms and evolution of human diseases. Main processes such as cell death, inflammation, environmental pathologies and genetic diseases, which are fundamental for understanding disease development and progression, will be considered. A group of lessons will be dedicated to oncology for understanding biomolecular mechanisms involved in tumor development and growth, as well as becoming familiar with tumor nomenclature and classification.
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Results of learning outcomes
Achievement of the knowledge on fundamental mechanisms of damage and disease processes regarding the impairment of tissue homeostasis, inflammatory responses, genetic disorders and cancer development and progression.
The knowledge is essential for a correct application on the different phases of the diseases (diagnosis/prognosis, therapy and prevention) in the next clinical courses.
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Program
GENERAL PATHOLOGY
- Tissue damage: adaptation conditions (hypertrophy, hyperplasia, atrophy, regression, metaplasia)
- Cell death: morphological, biochemical and molecular aspects of necrosis and apoptosis.
- Acute inflammation (Angiophlogosis): vascular and cellular events, exudate formation, inflammatory mediators (fluid phase and cellular mediators)
- Chronic inflammation (Histophlogosis): Classification and mechanism of unspecific and specific (granulomas) types of chronic inflammation
- Wound healing: tissue regeneration and repair
- Environmental causes of injury: physical (extreme temperatures and pressures; ionizing and non-ionizing radiation)
- Hyperthermia with/without fever: causes, mechanisms, stages and classification
- Genetic disorders: pathogenesis of different dominant/recessive disorders
- Oncology:
- Definition of neoplasia. The neoplastic multiphasic process
- Neoplastic proliferation - Oncogenes and tumor suppressor genes
- Cancer growth and invasiveness: molecular mechanisms of tumor infiltration and angiogenesis, epithelial-mesenchymal transition
- Tumor metastases - principal routes of cancer spreading
- Inflammation and cancer
- Epidemiology and classification of tumors. Tumor grading and staging
- Cancer etiology: chemical, physical, biological and genetic causes
- Tumor metabolism and cachexia
- Hereditary cancers
- Paraneoplastic syndroms
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Course delivery
General Pathology module will be provided through lessons onsite and slides will be uploaded on both Moodle platform and Campusnet website.
- Exercises for Basic Pathology: in order to clarify principal lesson topics, exercises/quizzes and deepening lectures will be provided; exercise activities consist of microscopic observations of pathological tissue specimens. Seminars may be provided in order to give deep information and improve lesson topics.
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Learning assessment methods
General Pathology module: oral exam in presence; the exam consists in 2-3 questions. Oral exams are public, so students who want to listen the exam can attend it.
The module mark is expressed in thirtieths.
The final mark of the exam will be the weighted media between the Basic Immunology module (4 CFU) and the General Pathology module (6 CFU).
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Support activities
General Pathology - Students with disabilities that may affect learning are encouraged to contact the lecturers to adapt learning materials, activities and testing methods.
Suggested readings and bibliography
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Robbins & Cotran Pathologic Basis of Disease, 9th Edition, Vinay Kumar, Abul Abbas, Jon Aster, Elsevier Ed.
Basic Pathology: An introduction to the mechanisms of disease, Sue E. Huether, Kathryn L. McCance, Elsevier - Health Sciences Division, 2019
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Notes
For any need, teachers will be reachable at their email address
Students with DSA or disabilities are kindly requested to take note of the reception services and support services offered by the University of Turin, and in particular of the procedures required for exam support.
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