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Basic pathology and immunology - Module of General pathology

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Basic pathology and immunology - Module of General pathology

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Academic year 2024/2025

Course ID
SCB0205A
Teachers
Fiorella Biasi (Lecturer)
Gabriella Marisa Leonarduzzi
Paola Francesca Gamba
Year
2nd year
Teaching period
First semester
Type
Basic
Credits/Recognition
6 (48 hours of lectures, 24 hours of exercises)
Course disciplinary sector (SSD)
MED/04 - experimental medicine and pathophysiology
Delivery
E-learning
Language
English
Attendance
Mandatory
Type of examination
Oral
Type of learning unit
modulo
Modular course
Basic Pathology and Immunology (SCB0205)
Prerequisites
Basic knowledge of cell biology, histology and anatomy in order to understand the causes and the mechanisms of damage.
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Sommario del corso

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Course objectives

General Pathology objectives: this part of the course will provide molecular basis for understanding causes, mechanisms and evolution of human diseases. Main processes such as necrosis, inflammation and tissue degeneration, which are fundamental for understanding disease development and progression, will be considered. A group of lessons will be dedicated to ONCOLOGY for understanding biomolecular mechanisms involved in tumor development and growth, as well as becoming familiar with tumor nomenclature and classification.

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Results of learning outcomes

Achievement of the knowledge on fundamental  mechanisms of damage and recognizing disease processes regarding the impairment of tissue homeostasis, immune responses, cancer development and progression, the main classifications.

The knowledge is essential for a correct application on the different phases of the diseases (diagnosis/prognosis, therapy and prevention) in the next clinical courses.

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Program

GENERAL PATHOLOGY

  • Tissue damage: adaptation conditions (hypertrophy, hyperplasia, atrophy, regression, metaplasia, dysplasia)
  • Cell death: morphological, biochemical and molecular aspects of necrosis and apoptosis. The role of cellular redox balance
  • Acute inflammation (Angiophlogosis): structure and function of the blood microvascular system. Exudate formation
  • Inflammatory mediators: fluid phase mediators and cellular mediators
  • Chronic inflammation (Histophlogosis): Classification and mechanism of formation of different unspecific and specific (granulomas) types of chronic inflammation
  • Wound healing: tissue regeneration and reintegration
  • Environmental causes of damage: physical (extreme temperatures and pressures; ionizing and non-ionizing radiation) and chemical factors
  • Fever: causes, mechanisms, stages and classification
  • Degenerative processes: thesaurismoses by lysosomal enzyme deficit, alcoholic and non-alcoholic steatosis, fibrosis and sclerosis, hepatic cirrhosis
  • Oncology:
    • Definition of neoplasia. The neoplastic multiphasic process
    • Normal and neoplastic proliferation - Oncogenes and tumor suppressor genes
    • Cancer growth and invasiveness: molecular mechanisms of tumor infiltration and angiogenesis
    • Tumor metastases - principal routes of cancer spreading
    • Epidemiology and classification of tumors. Tumor grading and staging
    • Cancer etiology: chemical, physical, biological and genetic causes
    • Inflammation and cancer. Epithelial-mesenchymal transition
    • Tumor cachexia
    • Hereditary cancers
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Course delivery

The course mainly consists of lectures associated with exercise activities.

General Pathology module will be provided through lessons onsite  and slides (as well as recorded lessons) will be uploaded on the Moodle platform. Slides will also be provided on the campusnet website.

  • Exercises for Basic Pathology: in order to clarify principal lesson topics, exercises/quizzes and deepening lectures will be provided online through Webex platform as scheduled: exercise activities will consist of microscopic visualization of pathological tissue specimens. Active discussion, quizzies and seminars will be provided in order to give deep information and improve the topics of the lessons.
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Learning assessment methods

General Pathology module: oral exam in presence; the exam consists in 2-3 questions. Oral exams are public, so students who want to listen the exam can attend it.

The module mark is expressed in thirtieths.

The final mark of the exam in the whole (expressed in thirtieths) will be the weighted media between Basic Immunology module (4 CFU) and General Pathology module (6 CFU): [(Immunology mark x4) + (Pathology mark x 6)]/10.

The mark of each module can be preserved only for the next exam date.

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Support activities

General Pathology - Students with disabilities that may affect learning are encouraged to contact the lecturers to adapt learning materials, activities and testing methods.

Suggested readings and bibliography

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Robbins & Cotran Pathologic Basis of Disease, 9th Edition, Vinay Kumar, Abul Abbas, Jon Aster, Elsevier Ed.



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Notes

For any need, teachers will be reachable at their email address

Students with DSA or disabilities are kindly requested to take note of the reception services and support services offered by the University of Turin, and in particular of the procedures required for exam support.

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Last update: 29/11/2023 14:15
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