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ADE - INTRODUCTION TO MEDICAL BIOCHEMISTRY

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Academic year 2024/2025

Course ID
SCB0309
Teachers
Marco Arese (Lecturer)
Alberto Puliafito (Lecturer)
Year
1st year
Teaching period
To be defined
Type
Elective
Credits/Recognition
2
Course disciplinary sector (SSD)
BIO/10 - biochemistry
Delivery
Lecture
Language
English
Attendance
Mandatory
Type of examination
Practice test
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Sommario del corso

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Course objectives

The ADE aims at reviewing the recent scientific history of cancer therapy with particular attention to the biochemical aspects. The topics covered are meant to recall concepts and ideas developed during the biochemistry courses of the first year.

Cancer's history is reviewed by its many paradigmatic aspects. Milestone scientific discoveries are explained through the detailed analysis of relevant scientists and their contributions. The students are asked to read and elaborate their own independent thought on such issues, by correctly identifying the main bibliographic records, citing them appropriately and by writing their thoughts in an informal yet scientifically sound style.

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Results of learning outcomes

Students are expected to learn to search on PubMed, PubChem and biomedical databases, to familiarize with scientific literature on technical cancer-related biomedical research, and to express their own view on scientific milestones. 

At the end of the ADE students will be asked to answer a set of question on a documentary on cancer. The written assays will be manually corrected by the teacher which will provide feedback. Evaluation criteria include:

  • accurate presentation of assigned authors’ viewpoints
  • presence of a personal view on the subjects
  • correct referencing of published works
  • scientifically soundness and writing style.
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Program

Overview of the path to modern approaches in cancer therapy, with references to its biochemical basis.

Documentary The emperor of all maladies, a brief history of cancer

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Course delivery

Interactive lectures with references to experimental work and data explanation. There will be a presentation lecture with definition of learning objectives, teaching tools and assessment methods. 

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Learning assessment methods

Written essays on Moodle with personal research work on the subjects described in the documentary. 

Teachers will correct and evaluate the text and assign a pass/no pass score.

Presence is mandatory during the presentation lecture.

Suggested readings and bibliography

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  1. S. Mukherjee, The Emperor of All Maladies: A Biography of Cancer, 2010;
  2. Hanahan and Weinberg, The hallmarks of cancer, Cell, 2000;
  3. Druker et al, Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-;Abl positive cells, Nat Med, 2 (5), 1996;
  4. H. Rubin, The early history of tumor virology: Rous, RIF, and RAV, PNAS, 108 (35), 2011;
  5. V. De Vita and E. Chu, A History of Cancer Chemotherapy, Canc. Research, 68 (21), 2008
  6. GS Martin, The hunting of the src, Nature Rev Mol Cell Biol, (2001), 2 (6)
  7. Shepard et al, Herceptin, Handb Exp Pharmacol., 2008, (181)
  8. S. Sigismund et al, Emerging functions of the EGFR in cancer, Mol. Oncol. 2018 12 (1)
  9. Miller DR, A tribute to Sidney Farber-- the father of modern chemotherapy, Br J Haematol., 2006, 134 (1)


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Notes

Min. number of students: 4

Maximum number of students: 30

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Class scheduleV

Lessons: from 08/07/2024 to 09/07/2024

Notes: form h 9;00

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