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Nephrology, Rheumatology and Clinical Immunology

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Nephrology, Rheumatology and Clinical Immunology

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Academic year 2023/2024

Course ID
SCB0220
Teachers
Dario Roccatello (Coordinator)
Savino Sciascia (Lecturer)
Roberta Fenoglio (Lecturer)
Annamaria Iagnocco (Lecturer)
Alessandro Morotti (Lecturer)
Elisa Menegatti (Lecturer)
Year
4th year
Teaching period
First semester
Type
Basic
Credits/Recognition
6 (48 hours of lectures, 24 hours of exercises)
Course disciplinary sector (SSD)
INF/01 - informatics
MED/09 - internal medicine
MED/14 - nephrology
MED/16 - rheumatology
Delivery
Formal authority
Language
English
Attendance
Mandatory
Type of examination
Written and oral
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Sommario del corso

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Course objectives

This course will provide a foundation in knowledge and skills necessary for medical students to recognize the most important medical problems and to construct clinical reasoning models in the field of nephrology, rheumatology and clinical immunology.
Upon successful completion of this course, students will be able to demonstrate the knowledge, attitudes and skills needed to indentify and  provide basic care for patients with nephrology, rheumatologic and immunologic diseases.
Students will be able to formulate a differential diagnosis, assessment and a prioritized plan for the standardized patient.

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Results of learning outcomes

Demonstrate knowledge, clinical and technical skills and decision-making capabilities pertinent to the management of patients with medical problems in the field of nephrology, rheumatology and clinical immunology.

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Program

Nephrology

  • Assessment of Glomerular Filtration Rate.
  • Urinalysis.
  • Disorders of Sodium and Potassium Metabolism.
  • Approach to Acid-Base Disorders.
  • Glomerular Clinicopathologic Syndromes.
  • Minimal Change Disease.
  • Focal Segmental Glomerulosclerosis.
  • Membranous Nephropathy.
  • Immunoglobulin A Nephropathy.
  • Goodpasture Syndrome and Other Antiglomerular Basement Membrane Diseases.
  • Postinfectious Glomerulonephritis.
  • Renal involvement in systemic vasculitis (granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis).
  • Henoch-Schönlein Purpura Nephritis (IgA vasculitis).
  • Lupus Nephritis.
  • Pathogenesis, Pathophysiology, and Treatment of Diabetic Nephropathy.
  • Dysproteinemias related disorders.
  • Amyloidosis.
  • Thrombotic Microangiopathies and aPL Nephropathy.
  • The Kidney in Cancers.
  • Acute Kidney Injury.
  • Polycystic and Other Cystic Kidney Diseases and Nephronophthisis and Medullary Cystic Kidney Disease.
  • Alport Syndrome and Related Disorders.
  • Fabry Disease.
  • Chronic Tubulointerstitial Disease.
  • Nephrolithiasis.
  • Urinary Tract Infection and Pyelonephritis.
  • Pregnancy in immunomediated and kidney diseases.
  • Chronic Kidney Disease and its Therapy.
  • Kidney Replacement Therapies: Dialysis and Transplantation.

Rheumatology

  • Introductory Aspects of RMDs.
  • Inflammatory Arthropathies.
  • Rheumatoid arthritis.
  • Spondyloarthritis.
  • The concept of Spondyloarthritis.
  • Ankylosing Spondylitis.
  • Psoriatic arthritis.
  • Enteropathic arthritis.
  • Reactive arthritis.
  • Undifferentiated Spondyloarthritis.
  • Autoinflammatory Syndromes.
  • Familial Mediterrannean Fever.
  • Adult Still Disease.
  • IGG4-related Disease.
  • Connective Tissue Diseases:
    • Systemic Lupus Erythematosus;
    • Antiphospholipid Syndrome;
    • Systemic Sclerosis;
    • Sjögren Syndrome;
    • Overlap Syndromes;
    • Mixed Connective Tissue Disease;
    • Undifferentiated Connective Tissue Disease.
  • Polymyositis and Dermatomyositis.
  • Polymyalgia Rheumatica and Giant Cell Arteritis.
  • Vasculitis.
  • Giant Cell Arteritis.
  • Takayasu’s arteritis.
  • Kawasaki Disease.
  • Polyarteritis nodosa.
  • ANCA-vasculitis.
  • Behçet Disease.

Clinical Immunology

  • Allergic diseases (including Extrinsic allergic alveolitis).
  • Immunodeficiencies.
  • Complements defects.
  • Phagocyte deficiencies and basophils/eosinophils diseases.
  • Sarcoidosis.
  • Idiopathic lung fibrosis.
  • Oncoimmunology.
  • Drug hypersensitivity.
  • Glucocorticoids, immunoglobulin-therapy and immunomodulating drugs.

Proteomics and Genomics

  • Laboratory assessment of immune-mediated diseases:
    • Principles of EIA and IF techniques;
    • ANA, anti DNA, ENA, ANCA, Ra Test, Anti-CCP, cryoglobulin detection, Antiphospholipid antibody detection.
  • Big data analyses.
  • Principles of NGS procedures.
  • Genomics and phenotypes.
  • Proteomic approches to diagnosis and therapy.
  • Mosaics in Autoimmunity (Yehuda Shoenfeld lectures).
  • Immune-neurological diseases.
  • ASIA syndrome and Sylicosis.
  • Sclerodermic disorders.
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Course delivery

Lectures in presence, supported/supplemented by recorded lectures that the students can access online through the platform Moodle

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Learning assessment methods

The exam test covers all the disciplines included in the course and the final score proportionally takes into account results of each module.

EXAMINATION ARRANGEMENTS: written and oral.

  • WRITTEN:
    • MED/05 - Clinical Pathology;
    • MED/09 - Internal Medicine;
    • MED/15 – Rheumatology.
  • ORAL:
    • MED/14 – Nephrology.

  • Proteomics exam: 20 questions, brief open answers, 30 min time. No penalties for incorrect answers.
  • Immunology exam: Multiple choice test. 31 questions. 20 min time. No penalties for incorrect answers.
  • Rheumatology exam:  Multiple choice test. 31 questions. 20 min time. No penalties for incorrect answers.
  • Nephrology exam: oral exam.
Partial scores kept valid until the next exam.
 
 

Final evaluation of the course will be the result of the weighted average of the scores of the single modules.


MED/05 - Clinical Pathology (1 CFU)
MED/09 - Internal Medicine (1 CFU)
MED/14 – Nephrology (3 CFU)
MED/15 – Rheumatology (1 CFU)


Professors are available upon mail contact.

Suggested readings and bibliography



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Book
Title:  
Clinical Immunology: Principles and Practice
Year of publication:  
2019
Publisher:  
Elsevier
Author:  
Robert R. Rich (ed.)
ISBN  
Permalink:  
Required:  
Yes


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Book
Title:  
Harrison's Principles of Internal Medicine, 20e
Year of publication:  
2018
Publisher:  
McGraw-Hill
Author:  
J. Larry Jameson, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo, Joseph Loscalzo
ISBN  
Permalink:  
Required:  
Yes


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Book
Title:  
EULAR Textbook of Rheumatology
Year of publication:  
2018
Publisher:  
EULAR
Author:  
EULAR
Permalink:  
Required:  
Yes


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Book
Title:  
Laposata's Laboratory Medicine: Diagnosis of Disease in the Clinical Laboratory, 3e
Year of publication:  
2018
Publisher:  
McGraw-Hill
Author:  
Michael Laposata
ISBN  
Permalink:  
Required:  
Yes


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Book
Title:  
Immunoassay
Year of publication:  
1996
Publisher:  
Elsevier
Author:  
Eleftherios P. Diamandis, Theodore K. Christopoulos
ISBN  
Permalink:  
Required:  
Yes


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Book
Title:  
Current Diagnosis & Treatment: Nephrology & Hypertension
Year of publication:  
2018
Publisher:  
McGraw Hill
Author:  
Edgar V. Lerma, Mitchell H. Rosner, Mark A. Perazella
ISBN  
Permalink:  
Required:  
Yes


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Book
Title:  
Oxford Textbook of Clinical Nephrology: Three-Volume Pack (4 edn)
Year of publication:  
2019
Publisher:  
Oxford University Press
Author:  
Neil N. Turner (ed.), Neil N. Turner (ed.), Norbert Lameire (ed.), David J. Goldsmith (ed.), Christopher G. Winearls (ed.), Jonathan Himmelfarb (ed.), Giuseppe Remuzzi (ed.)
ISBN  
Permalink:  
Required:  
Yes


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Notes

Students with DSA or disabilities are kindly requested to take note of the reception services and support services offered by the University of Turin, and in particular of the procedures required for exam support.

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Teaching Modules

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Last update: 29/11/2023 14:15
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