MedInTO Medicine and Surgery

Selected research products

1. Ghia P, Strola G, Granziero L, Geuna M, Guida G, Dallusto F, Ruffing N, Montagna L, Piccoli P, Chilosi M, Caligaris-Cappio F. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract T cells by producing CCL22. EUROPEAN JOURNAL OF IMMUNOLOGY. 2002; 32:1403-1413
2. Ghia P, Guida G, Stella S, Gottardi D, Geuna M, Strola G, Scielzo C, and Caligaris-Cappio F. The Pattern of CD38 expression defines a distinct subset of chronic Lymphocytic leukemia (CLL) patients at risk of diesease progression.   2003; 101(4):1262-1269. 
3. Rolla G, Nebiolo F, Guida G, Marsico P, Riva G, Zanotta S. Cotton wool in pine trees. The LANCET. 2003; 361:44. (Elsevier –US) SCOPUS: 2-s2.0-0037417491
4. Ghia P, Prato G, Scielzo C, Stella S, Geuna M, Guida G, and Caligaris-Cappio F. Monoclonal CD5+ and CD5- B-lymphocyte expantions are frequent in the peripheral blood of the elderly. Blood. 2004; 103 (6):2337-2342. (American Society of Hematology - Washington, DC –US)
5. Ghia P, Guida G, Scielzo C, Geuna M and Caligaris-Cappio F.  CD38 modifications in chronic lymphocytic leukemia: are they relevant? Leukemia. 2004 Oct;18(10):1733-5. Review (Nature Publishing Group Houndmills Basingstoke Hampshire UK)
6. Rolla G,Nebiolo F, Marsico P, Guida G, Bigo P, Riva G, Zanotta S. Allergy to Pigeon Tick Argas Reflexus: Demonstration of Specific IgE-   binding Component. International Archives of Allergy and Immunology 2004; 135: 293-295. ( Karger A Basel - Switzerland)
7. Ghia P, Stamatopulos K, Belessi C, Moreno C, Stella S, Guida G, Michel A, Crespo M, Laoutaris N, Monserrat E, Anagnostopoulos A, Dighiero G, Fassas A, Caligaris-Cappio F, Davi F. Geographic patterns and pathogenetic implication of IGHV gene usage in Chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood. 2005; 105: 1678-1685. (American Society of Hematology - Washington, DC –US)
8. Guida G, Nebiolo F, Heffler E, Bergia R and Rolla G. Anaphylaxis after a horse bite. Allergy 2005;60:1088-1089. (John Wiley & Sons, Ltd. – Chichester, West Sussex, UK)
9. Cristina Scielzo, Paolo Ghia, Antonio Conti, Angela Bachi, Giuseppe Guida, Massimo Geuna, Massimo Alessio and Federico Caligaris-Cappio HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses.JCI 2005; 115: 1644-1650. (The American Society for Clinical Investigation- Ann Arbor, MI.US)
10. Rolla G, , Nebiolo F, Guida G, Heffler E, Bergia R. Exhaled Nitric Oxide in Diffuse Alveolar Hemorrhage. Thorax 2005, Jul;60(7):614-5. (BMJ Publishing Group Ltd & British Thoracic Society - London UK)
11. Rolla, L Bommarito, E. Heffler, G. Guida, N. Ferrero, R. Bergia, I. Badiu, F. Nebiolo. Exhaled nitric oxide in asthma. It J Allergy Clin Immunol 2006; 16:141-150 (Pacini Editore – Pisa, Italia)
12. Enrico Heffler, Giuseppe Guida, Pietro Marsico, Roberta Bergia, Luisa Bommarito, Nicoletta Ferrero, Franco Nebiolo, Antonella De Stefani, Antonio Usai, Caterina Bucca and Giovanni Rolla^, Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms. Respir Med 2006;100:1981-1987. (Reed Elsevier Group - London, UK)
13. Giovanni Rolla, Franco Nebiolo, Giuseppe Guida, Enrico Heffler, Luisa Bommarito, Roberta Bergia. Level of exhaled nitric Oxide during human anaphylaxis. Ann Allergy Asthma Immunol 2006;97:264-265. (Reed Elsevier Group - London, UK)
14. R Zanotti, A Ambrosetti, M Lestani, P Ghia, C Pattaro, A Remo, F Zanetti, S Stella, O Perbellini, G Prato, G Guida, F Caligaris-Cappio, F Menestrina, G Pizzolo and M Chilosi. ZAP-70 expression, as detected by immunohistochemistry on bone marrow biopsies from early-phase CLL patients, is a strong adverse prognostic factor. Leukemia (2007) 21, 102–109. (Nature Publishing Group Houndmills Basingstoke Hampshire UK)
15. Kostas Stamatopoulos, Chrysoula Belessi, Carol Moreno, Myriam Boudjograh, Giuseppe Guida, Tatjana Smilevska, Lynda Belhoul, Stefania Stella, Niki Stavroyianni, Marta Crespo, Anastasia Hadzidimitriou, Laurent Sutton, Francesc Bosch, Nikolaos Laoutaris, Achilles Anagnostopoulos, Emili Montserrat, Athanasios Fassas, Guillaume Dighiero, Federico Caligaris-Cappio, Hélène Merle-Béral, Paolo Ghia, and Frédéric Davi^. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped    receptors: pathogenetic implications and clinical correlations. Blood, 1 January 2007,   109, No. 1,pp. 259-270. .  (American Society of Hematology - Washington, DC –US)
16. Rolla G, Tartaglia N, Motta M, Ferrero N, Bergia R, Guida G, Heffler E..Warning nonrespiratory symptoms in asthma: catastrophic abdominal involvement in a case of Churg-Strauss syndrome. Ann Allergy Asthma Immunol. 2007 Jun;98(6):595-7(Reed Elsevier Group - London, UK)
17. Bommarito L, Migliore E, Bugiani M, Heffler E, Guida G, Bucca C, de Marco R, Rolla G. Exhaled Nitric Oxide in a Population Sample of Adults. Respiration. 2008;75(4):386-92. (S.Karger A.G. – Basel, Switzerland)
18. Rolla G, Guida G, Heffler E, Badiu I, Bommarito L, De Stefani A, Usai A, Cosseddu D, Nebiolo F, Bucca C. Diagnostic classification of persistent rhinitis and its relationship to exhaled nitric oxide and asthma: a clinical study of a consecutive series of patients.Chest. 2007 May;131(5):1345-52. Epub 2007 Feb 22. (American College of Chest Physicians - Northbrook, Illinois, USA)
19. Heffler E, Guida G, Badiu I, Nebiolo F, Rolla G. Anaphylaxis after eating Italian pizza containing buckwheat as the hidden food allergen. J Investig Allergol Clin Immunol. 2007;17(4):261-3. (ESMOND Publicidad S.A. – Barcelona, Spain)
20. Rolla G, Guida G, Heffler E. (2007). Churg-Strauss syndrome: still a clinical challenge?. Expert Review of Clinical Immunology. vol. 3 (6) 833-837 (2007) (Expert Reviews Ltd. - London, UK)
21. Rolla G, Heffler E, Bommarito L, Guida G, Badiu I, Bergia R, Marsico P, Pizzimenti S, Nebiolo F. Exhaled nitric oxide in persistent rhinitis with or without lower airway involvement: a review of the Literature. J Breath Res., december 2007. (IOP Publishing Ltd. – Bristol, UK)
22. Guida G, Vallario A, Stella S, Boita M, Circosta P, Mariani S, Prato G, Heffler E, Bergia R, Sottile A, Rolla G, Cignetti A.Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome. Clin Immunol. 2008 Jul;128(1):94-102. Epub 2008 May 23. (Reed Elsevier Group - London, UK)
23. Pizzimenti S, Bugiani M, Piccioni P, Heffler E, Carosso A, Guida G, Rolla G. Exhaled nitric oxide measurements: Correction equation to compare hand-held device to stationary analyzer. Respir Med. 2008 Sep;102(9):1272-5 (Reed Elsevier Group - London, UK)
24. Bommarito L, Guida G, Heffler E, Badiu I, Nebiolo F, Usai A, De Stefani A, Rolla G. Nasal nitric oxide concentration in suspected chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2008 Oct;101(4):358-62. (Reed Elsevier Group - London, UK)
25. Rolla G, Bruno M, Bommarito L, Heffler E, Ferrero N, Petrarulo M, Bagnis C,Bugiani M, Guida G. Breath analysis in patients with end-stage renal disease: effect of haemodialysis. Eur J Clin Invest. 2008 Oct;38(10):728-33. (John Wiley & Sons, Ltd. – Chichester, West Sussex, UK)
26. Bucca C, Culla B, Asioli S, Rabbia F, Milan A, Limerutti G, Guida G. Severe episodic dyspnoea and abnormal flow-volume loop. Extramedullary plasmacytoma (EMP). Thorax. 2009 Mar;64(3):210, 264. (BMJ Publishing Group Ltd – UK)
27. Nebiolo F, Bergia R, Bommarito L, Bugiani M, Heffler E, Carosso A, Castiglioni G, Guida G, Badiu I, Pizzimenti S, Mietta S, Ferrero N, Rolla G. Effect of arterial hypertension on chronic urticaria duration. Ann Allergy Asthma Immunol. 2009 Nov;103(5):407-10. (Reed Elsevier Group - London, UK)
28. Culla B, Guida G, Brussino L, Tribolo A, Cicolin A, Sciascia S, Badiu I, Mietta S, Bucca C. Increased oral nitric oxide in obstructive sleep apnoea. Respir Med. 2010 Feb;104(2):316-20. Respir Med. 2009 Oct 22. (Reed Elsevier Group - London, UK)
29. Guida G, Rolla G, Badiu I, Marsico P, Pizzimenti S, Bommarito L, De Stefani A, Usai A, Bugiani M, Malinovschi A, Bucca C, Heffler E. Determinants of exhaled nitric oxide in chronic rhinosinusitis. Chest. 2010 Mar;137(3):658-64. Chest. 2009 Oct 16. (American College of Chest Physicians - Northbrook, Illinois, USA)
30. Giuseppe Guida, Beatrice Culla, Tiziana Scirelli , Graziella Bellone, Savino Sciascia, Luisa Brussino, Domenico Novero, Giorgio Palestro, Enrico Heffler, Paolo Gavarotti,, Giovanni Rolla, and Caterina Bucca. Exhaled nitric oxide and nitric oxide synthase expression in Hodgkin’s disease. International Journal of immunopathology and pharmacology, Vol 22 no 4, 1027-1034 (2009) (Biolife S.a.S – Chieti, Italia).
31. Caterina B. Bucca, Massimiliano Bugiani, Beatrice Culla, Giuseppe Guida, Enrico Heffler, Sabrina Mietta,Antonella Moretto, Giovanni Rolla, and Luisa Brussino.Chronic cough and irritable larynx. Journal of Allergy and Clinical Immunology, october 2010, in press. doi:10.1016/j.jaci.2010.10.038. J Allergy Clin Immunol. 2011 Feb;127(2):412-9. Epub 2010 Dec 16
32. Heffler E, Nebiolo F, Asero R, Guida G, Badiu I, Pizzimenti S, Marchese C, Amato S, Mistrello G, Canaletti F, Rolla G. Clinical manifestations, co-sensitizations, and immunoblotting profiles of buckwheat-allergic patients 2010 Aug 30. [Epub ahead of print] AllergyVolume 66, Issue 2, pages 264–270, February 2011
33. Brussino L, Badiu I, Sciascia S, Bugiani M, Heffler E, Guida G, Malinovschi A, Bucca C, Rolla G. Oxidative stress and airway inflammation after allergen challenge evaluated by exhaled breath condensate analysisClin Exp Allergy. 2010 Nov;40(11):1642-7. doi: 10.1111/j.1365-2222.2010.03604.x. Epub 2010 Aug 18.
34. Scurati S, Frati F, Passalacqua G, Puccinelli P, Hilaire C, Incorvaia C; Italian Study Group on SLIT Compliance: Collaborators: Guida G,  . Adherence issues related to sublingual immunotherapy as perceived by allergists. Patient Prefer Adherence. 2010 Jun 24;4:141-5. PMCID: PMC2898115. PMID: 20622914  [PubMed]
35. Bucca CB, Culla B, Guida G, Sciascia S, Bellone G, Moretto A, Heffler E, Bugiani M, Rolla G, Brussino L. Unexplained chronic cough and vitamin B-12 deficiency Am J Clin Nutr. 2011 Mar;93(3):542-8. Epub 2011 Jan 19.
36. Bucca C, Brussino L, Maule MM, Baldi I, Guida G, Culla B, Merletti F, Foresi A, Rolla G, Mutani R, Cicolin A. Clinical and functional prediction of moderate to severe obstructive sleep apnoea Clin Respir J. 2011 Oct;5(4):219-26. doi: 10.1111/j.1752-699X.2010.00223.x. Epub 2010 Sep 22.
37. Bucca C, Cicolin A, Guida G, Heffler E, Brussino L, Rolla G. Exhaled nitric oxide (FENO) in non-pulmonary diseases. J Breath Res. 2012 Jun;6(2):027104. Epub 2012 May 2.
38. Boita M, Rolla G, Mallone R, Martinuzzi E, Heffler E, Circosta P, Elia AR, Cignetti A, Caillat-Zucman S, de Menthon M, Guida G. Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome. Clin Exp Rheumatol. 2012 Jan-Feb;30(1 Suppl 70):S57-61. Epub 2012 May 14.
39. Martorana D, Maritati F, Malerba G, Bonatti F, Alberici F, Oliva E, Sebastio P, Manenti L, Brugnano R, Catanoso MG, Fraticelli P, Guida G, Gregorini G, Possenti S, Moroni G, Leoni A, Pavone L, Pesci A, Sinico RA, Di Toma L, D'Amico M, Tumiati B, D'Ippolito R, Buzio C, Neri TM, Vaglio A. PTPN22 R620W polymorphism in the ANCA-associated vasculitides Rheumatology (Oxford). 2012 May;51(5):805-12. Epub 2012 Jan 11.
40. Guida G, Boita M, Scirelli T, Bommarito L, Heffler E, Badiu I, Bellone G, Mietta S, Mistrello G, Rolla G. Allergy Asthma Proc. 2012 Sep;33(5):411-5. doi: 10.2500/aap.2012.33.3588. Epub 2012 Jul 3. Innate and lymphocytic response of birch-allergic patients before and after sublingual immunotherapy
41. Bertero MT, Bazzan M, Carignola R, Montaruli B, Silvestro E, Sciascia S, Vaccarino A, Baldovino S, Roccatello D; Antiphospholipid Piedmont Consortium. Collaborators : Giachino O, Marletto F, Sosso L, Marozio L, Data V, Guida G, Bigo P, Stella S, Rollino C, Ferro M, Colla L, Karvela E, Pellerito R, Bellis E, Maina A, Donvito V, Nicolino B, Schinco P, Sivera P, Kuzenko A, Napolitano E, Cosseddu D, Marchese C, Romeo N, Seminara G, Stefanidou EM, Molinari F, Contino L, Santi R, Nallino MG, Calvi R, Stratta P, Bizzocchi A, Bobbio F, Sainaghi PP, Sola D. Antiphospholipid syndrome in northwest Italy (APS Piedmont Cohort): demographic features, risk factors, clinical and laboratory profile. Lupus. 2012 Jun;21(7):806-9.
42. M Bazzan, A Vaccarino, S Stella, M T Bertero, R Carignola, B Montaruli, D Roccatello, Y Shoenfeld, Piedmont APS Consortium: Osvaldo Giachino, Marletto Fabio, Simone Baldovino, Luisa Sosso, Luca Marozio, Valeria Data, Giuseppe Guida, Patrizia Bigo, Cristiana Rollino, Michela Ferro, Colla Loredana, Eirini Karvela, Raffaele Pellerito, Bellis Emanuela, Aldo Maina, Valentino Donvito, Barbara Nicolino, Piercarla Schinco, Piera Sivera, Anna Kuzenko, Emanuela Napolitano, Domenico Cosseddu, Cristiana Marchese, Nicoletta Romeo, Giulia Seminara, Maria Stefanidou Erato, Fillippo Molinari, Laura Contino, Roberto Santi, Maria Gabriella Nallino, Roberta Calvi, Piero Stratta, Agata Bizzocchi, Bobbio Flavio, Pier Paolo Sainaghi, Daniele Solo.Thrombotic recurrences and bleeding events in APS vascular patients: a review from the literature and a comparison with the APS Piedmont Cohort. Autoimmun Rev 2013 Jun;12(8):826-31. doi: 10.1016/j.autrev.2012.11.007. Epub 2012 Dec 4.
43. Heffler, P.L. Minciullo, F. Fasio, F.W. Rossi, M. Patafi, M. Mondino, I. Badiu, G. Guida on behalf of Junior Members working group of Italian Society of Allergy and Clinical Immunology (SIAIC) Pertinence of requested allergy consultations for suspected food allergy/intolerance. A Junior Members working group of Italian Society of Allergy and Clinical Immunology (SIAIC) multicenter study It j allergy clin immunol 2011;21:18-24
44. Badiu I, Olivieri E, Montagni M, Guida G, Mietta S, Pizzimenti S, Caminati M, Yacoub MR, Tombetti E, Preziosi D, Quecchia C, Minetti S, Facchetti S, Fassio F, Massaro I, Corradi L, Turi MC, Colagiovanni A, Pascolini L, Rossi FW, Losappio L, Sansone L, Imbesi S, Leto Barone S, Mistrello G, Heffler E. Italian study on buckwheat allergy: prevalence and clinical features of buckwheat-sensitized patients in Italy. Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):801-6.
45. Heffler E, Pizzimenti S, Badiu I, Guida G, Ricciardolo FL, Bucca C, Rolla G. Nasal nitric oxide is a marker of poor asthma control.J Breath Res. 2013 Jun;7(2):026009. doi: 10.1088/1752-7155/7/2/026009. Epub 2013 May 10
46. Enrico Heffler, Stefano Pizzimenti, Iuliana Badiu, Giuseppe Guida and Giovanni Rolla* Buckwheat Allergy: An Emerging Clinical Problem in Europe Heffler et al., J Allergy Ther 2014, 5http://dx.doi.org/10.4172/2155-6121.1000168
47. Monica Boita; Giuseppe Guida; Paola Circosta; Angela R Elia; Stefania Stella; Enrico Heffler; Iuliana Badiu; Davide Martorana; Sara Mariani; Giovanni  Rolla; Alessandro Cignetti. Molecular and functional characterization of clonally expanded CD8+ TCR BV T cells   in eosinophilic granulomatosis with polyangiitis (EGPA). Clin Immunol. 2014 May-Jun;152(1-2):152-63 Press http://dx.doi.org/10.1016/j.clim.2014.03.001
48. Badiu I,Guida G, Heffler E, Rolla G. Multiple Drug Allergy Due to Hypersensitivity to Polyethylene Glycols of Various Molecular Weights. J Investig Allergol Clin Immunol. 2015;25(5):368-9.
49. Martorana D, Bonatti F, Alberici F, Gioffredi A, Reina M, UrbanML, Maritati F, Adorni A, Radice A, Pizzolato S, Gregorini G,Jeannin G, Guida G, Boita M, Pesci A, Moroni G, Neri TM,Sinico RA, Vaglio A( Fcγ-receptor 3B (FCGR3B) copy number variations in patients with eosinophilic granulomatosis with polyangiitis. J Allergy Clin Immunol. 2015 Dec 9. pii: S0091-6749(15)01575-4. doi: 10.1016/j.jaci.2015.09.053. [Epub ahead of print]
50. Heffler E, Pizzimenti S, Guida G, Bucca C, Rolla G.. Prevalence of over-/misdiagnosis of asthma in patients referred to an allergy clinic. J Asthma. 2015 Nov;52(9):931-4. doi: 10.3109/02770903.2015.1026442. Epub 2015 Aug 18.
51. Heffler E, Bonini M, Brussino L, Solidoro P(4), Guida G, Boita M, Nicolosi G, Bucca C., Vitamin D deficiency and exercise-induced laryngospasm in young competitive rowers. Appl Physiol Nutr Metab. 2016 Jul;41:735-40
52. Heffler E, Landi M, Caruso C, Fichera S, Gani F, Guida G, Liuzzo MT, Pistorio MP, Pizzimenti S, Riccio AM, Seccia V, Ferrando M, Malvezzi L, Passalacqua G,Gelardi M. Nasal cytology: Methodology with application to clinical practice and research. Clin Exp Allergy. 2018 Sep;48(9):1092-1106. doi: 10.1111/cea.13207.Epub 2018 Jul 9. Review. PubMed PMID: 29904978.
53. Bagnasco D, Menzella F, Caminati M, Caruso C, Guida G, Bonavia M, Riccio A, Milanese M, Manfredi A, Senna G, Passalacqua G. Efficacy of mepolizumab in patients with previous omalizumab treatment failure: Real-life observation. 2019 Jun 5. doi: 10.1111/all.13937.
54. Guida G, Riccio AM. Immune induction of airway remodeling.Semin Immunol. 2019 Dec;46:101346. doi: 10.1016/j.smim.2019.101346. Epub 2019 Nov
55. Lyons PA, Peters JE, Alberici F, Liley J, Coulson RMR, Astle W, Baldini C, Bonatti F, Cid MC, Elding H, Emmi G, Epplen J, Guillevin L, Jayne DRW, Jiang T(3), Gunnarsson I, Lamprecht P, Leslie S, Little MA, Martorana D, Moosig F, Neumann T, Ohlsson S, Quickert S, Ramirez GA, Rewerska B, Schett G, Sinico RA, Szczeklik W, Tesar V, Vukcevic D; European Vasculitis Genetics Consortium, Terrier B, Watts RA, Vaglio A, Holle JU, Wallace C, Smith KGC. Collaborators: Akil M, Barratt J, Basu N, Butterworth AS, Bruce I, Clarkson M,Conlon N, DasGupta B, Doulton TWR, Espígol-Frigolé G, Flossmann O, Gabrielli A,Gasior J, Gregorini G, Guida G, Hernández-Rodríguez J, Hruskova Z, Hudson A,Knight A, Lanyon P, Luqmani R, Magliano M, Manfredi AA, Marguerie C, Maritati F, Marvisi C, McHugh NJ, Molloy E, Motyer A, Mukhtyar C, Padyukov L, Pesci A,Prieto-Gonzalez S, Ramentol-Sintas M, Reis P, Roccatello D, Rovere-Querini P, Salvarani C, Santarsia F, Solans-Laque R, Soranzo N, Taylor J, Wessels J, Zwerina.Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status. Nat Commun. 2019 Nov 12;10(1):5120. doi: 10.1038/s41467-019-12515-9
56. Bagnasco D, Caminati M, Menzella F, Milanese M, Rolla G, Lombardi C, Bucca C, Heffler E, Paoletti G, Testino E, Manfredi A, Caruso C, Guida G, Senna G, Bonavia M, Riccio AM, Canonica GW, Passalacqua G. One year of mepolizumab. Efficacy and safety in real-life in Italy Pulm Pharmacol Ther. 2019 Oct;58:101836. doi: 10.1016/j.pupt.2019.101836. Epub 2019 Aug 29.
57. Bagnasco D, Brussino L, Bonavia M, Calzolari E, Caminati M, Caruso C, D'Amato M, De Ferrari L, Di Marco F, Imeri G, Di Bona D, Gilardenghi A, Guida G, Lombardi C, Milanese M, Nicolini A, Riccio AM, Rolla G, Santus P, Senna G, Passalacqua G. Efficacy of Benralizumab in severe asthma in real life and focus on nasal polyposis. Respir Med. 2020 Sep;171:106080. doi: 10.1016/j.rmed.2020.106080. Epub 2020 Jul 3.
58. Heffler E, Detoraki A, Contoli M, Papi A, Paoletti G, Malipiero G, Brussino L, Crimi C, Morrone D, Padovani M, Guida G, Gerli AG, Centanni S, Senna G, Paggiaro P, Blasi F, Canonica GW; SANI Working Group. COVID-19 in Severe Asthma Network in Italy (SANI) patients: Clinical features, impact of comorbidities and treatments. Allergy. 2021 Mar;76(3):887-892. doi: 10.1111/all.14532. Epub 2020 Aug 20.
59. Canonica GW, Malvezzi L, Blasi F, Paggiaro P, Mantero M, Senna G, Heffler E; Severe Asthma Network Italy (SANI). Collaborators Severe Asthma Network Italy (SANI): M Bonavia, P Caiaffa, C Calabrese, G Camiciottoli, C Caruso, S Centanni, M E Conte, A G Corsico, L Cosmi, M T Costantino, N Crimi, S D'Alò, M D'Amato, S Del Giacco, E Favero, A Farsi, B P M Foschino, G Guarnieri, G Guida, M Latorre, C Lombardi, L Macchia, F Menzella, M Milanese, P Montuschi, E Nucera, R Parente, G Passalacqua, V Patella, G Pelaia, L Pini, F L M Ricciardolo, L Ricciardi, L Richeldi, E Ridolo, G Rolla, P Santus, N Scichilone, P Solidoro, G Spadaro, A Spanevello, A Vianello, M R Yacoub, M C Zappa Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry. Respir Med. 2020 May;166:105947. doi: 10.1016/j.rmed.2020.105947. Epub 2020 Apr 2.
60. Bagnasco D, Brussino L, Caruso C, Paoletti G, Heffler E, Guida G, Calzolari E, Nicola S, De Ferrari L, Passalacqua G, Canonica GW. Do the current guidelines for asthma pharmacotherapy encourage over-treatment? Expert Opin Pharmacother. 2020 Aug;21(11):1283-1286. doi: 10.1080/14656566.2020.1759551. Epub 2020 May 13.
61. Heffler E, Carpagnano GE, Favero E, Guida G, Maniscalco M, Motta A, Paoletti G, Rolla G, Baraldi E, Pezzella V, Piacentini G, Nardini S. Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). Multidiscip Respir Med. 2020 Feb 19;15(1):36. doi: 10.4081/mrm.2020.36. eCollection 2020 Jan 28.
62. Bagnasco D, Massolo A, Bonavia M, Brussino L, Bucca C, Caminati M, Canonica GW, Caruso C, D'Amato M, De Ferrari L, Guida G, Heffler E, Lombardi C, Menzella F, Milanese M, Paoletti G, Riccio AM, Rolla G, Senna G, Testino E, Passalacqua G. The importance of being not significant: Blood eosinophils and clinical responses do not correlate in severe asthma patients treated with mepolizumab in real life. Allergy. 2020 Jun;75(6):1460-1463. doi: 10.1111/all.14135. Epub 2020 Feb 23.
63. Giorgio Walter Canonica, Francesco Blasi, Pierluigi Paggiaro, Gianenrico Senna, Giovanni Passalacqua, Antonio Spanevello, Stefano Aliberti, Diego Bagnasco, Marco Bonavia, Matteo Bonini, Luisa Brussino, Caterina Bucca, Maria F Caiaffa, Cecilia Calabrese, Gianna Camiciottoli, Marco Caminati, Giovanna E Carpagnano, Cristiano Caruso, Stefano Centanni, Maria E Conte, Angelo G Corsico, Lorenzo Cosmi, Maria T Costantino, Nunzio Crimi, Simona D’Alò, Maria D'Amato, Stefano Del Giacco, Alessandro Farsi, Elisabetta Favero, Maria P Foschino Barbaro, Gabriella Guarnieri, Giuseppe Guida, Manuela Latorre, Salvatore Lo Cicero, Carlo Lombardi, Luigi Macchia, Francesco Mazza, Francesco Menzella, Manlio Milanese, Marcello Montagni, Paolo Montuschi, Eleonora Nucera, Roberta Parente, Vincenzo Patella, Girolamo Pelaia, Laura Pini, Francesca Puggioni, Luisa Ricciardi, Fabio LM Ricciardolo, Luca Richeldi, Erminia Ridolo, Giovanni Rolla, Pierachille Santus, Nicola Scichilone, Giuseppe Spadaro, Andrea Vianello, Vittorio Viviano, Mona R Yacoub, Maria C Zappa, Enrico Heffler. Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI). World Allergy Organ J. 2020 Sep 20;13(10):100464. doi: 10.1016/j.waojou.2020.100464. eCollection 2020 Oct.
64. Diego Bagnasco, Massimiliano Povero, Lorenzo Pradelli, Luisa Brussino, Giovanni Rolla, Marco Caminati, Francesco Menzella, Enrico Heffler, Giorgio Walter Canonica, Pierluigi Paggiaro, Gianenrico Senna, Manlio Milanese, Carlo Lombardi, Caterina Bucca, Andrea Manfredi, Rikki Frank Canevari, Giovanni Passalacqua, Gabriella Guarnieri, Vincenzo Patella, Foschino Barbaro Maria Pia, Elisiana Carpagnano, Anna del Colle, Giulia Scioscia, Pelaia Gerolamo, Manuela Latorre, Francesca Puggioni, Francesca Racca, Elisabetta Favero, Sandra Iannacone, Eleonora Savi, Marcello Montagni, Gianna Camiciottoli, Chiara Allegrini, Giuseppe Spadaro, Caterina Detoraki, Carla Galeone, Patrizia Ruggiero, Monna Rita Yacoub, Alvise Berti, Gisella Colombo, Nicola Scichilone, Carmen Durante, Maria Teresa Costantino, Chiara Roncallo, Mariachiara Braschi, Francesco Blasi, Alice D'Adda, Erminia Ridolo, Massimo Triggiani, Roberta Parente, Maria Vittoria Verrillo, Zappa Maria Cristina, Marianna Lilli, Nunzio Crimi, Marco Bonavia, Angelo Guido Corsico, Amelia Grosso, Stefano Del Giacco, Margherita Deidda, Luisa Ricciardi, Stefania Isola, Francesca Cicero, Giuliana Amato, Federica Vita, Antonio Spanevello, Patrizia Pignatti, Francesca Cherubino, Dina Visca, Eleonora Aletti, Fabio Luigi Massimo Ricciardolo, Vitina Maria Anna Carriero, Francesca Bertolini, Pierachille Santus, Roberta Barlassina, Andrea Airoldi, Giuseppe Guida, Nucera Eleonora, Arianna Aruanno, Angela Rizzi, Cristiano Caruso, Stefania Colantuono, Alessandra Arcolaci, Andrea Vianello, Fulvia Chieco Bianchi, Maria Rita Marchi, Stefano Centanni, Simone Luraschi, Silvia Ruggeri, Rocco Rinaldo, Elena Parazzini, Cecilia Calabrese, Martina Flora, Lorenzo Cosmi, Linda Di Pietro, Enrico Maggi, Laura Pini, Luigi Macchia, Danilo Di Bona, Luca Richeldi, Carola Condoluci, Leonello Fuso, Matteo Bonini, Alessandro Farsi, Giulia Carli, Paolo Montuschi, Giuseppe Santini, Maria Elisabetta Conte, Elisa Turchet, Carlo Barbetta, Francesco Mazza, Simona D'Alo, Stefano Pucci, Maria Filomena Caiaffa, Elena Minenna, Luciana D'Elia, Carlo Pasculli, Vittorio Viviano, Paolo Tarsia, Joyce Rolo, Mariacarmela Di Proietto, Salvatore Lo Cicero. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life. World Allergy Organization Journal, 2021. 14 (2), 100509
65. Bettiol A, Sinico RA, Schiavon F, Monti S, Bozzolo EP, Franceschini F, Govoni M, Lunardi C, Guida G, Lopalco G, Paolazzi G, Vacca A, Gregorini G, Leccese P, Piga M, Conti F, Fraticelli P, Quartuccio L, Alberici F, Salvarani C, Bettio S, Negrini S, Selmi C, Sciascia S, Moroni G, Colla L, Manno C, Urban ML, Vannacci A, Pozzi MR, Fabbrini P, Polti S, Felicetti M, Marchi MR, Padoan R, Delvino P, Caporali R, Montecucco C, Dagna L, Cariddi A, Toniati P, Tamanini S, Furini F, Bortoluzzi A, Tinazzi E, Delfino L, Badiu I, Rolla G, Venerito V, Iannone F, Berti A, Bortolotti R, Racanelli V, Jeannin G, Padula A, Cauli A, Priori R, Gabrielli A, Bond M, Tedesco M, Pazzola G, Tomietto P, Pellecchio M, Marvisi C, Maritati F, Palmisano A, Dejaco C, Willeit J, Kiechl S, Olivotto I, Willeit P, Prisco D, Vaglio A, Emmi G; Italian EGPA Consortium. Risk of acute arterial and venous thromboembolic events in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss syndrome) Eur Respir J. 2021 Apr 8:2004158. doi: 10.1183/13993003.04158-2020. Online ahead of print.
66. Heffler E, Detoraki A, Contoli M, Papi A, Paoletti G, Malipiero G, Brussino L, Crimi C, Morrone D, Padovani M, Guida G, Gerli AG, Centanni S, Senna G, Paggiaro P, Blasi F, Canonica GW; SANI Working Group. Reply to: Kow CS et al. Are severe asthma patients at higher risk of developing severe outcomes from COVID-19?. Allergy. 2021 Mar;76(3):961-962. doi: 10.1111/all.14593.
67. Giovanni Paoletti, Giulio Melone, Giuseppe Guida, Francesca Pirola, Luca Malvezzi, Corrado Pelaia, Alessia Mariani, Francesca Racca, Giacomo Malipiero, Sebastian Ferri, Francesca Puggioni, Giuseppe Spriano, Giorgio Walter Canonica, Enrico Heffler. Extended nitric oxide analysis in patients with chronic rhinosinusitis with nasal polyps, with or without associated asthma. J Breath Res. 2020 Nov 5;15(1):016007. doi: 10.1088/1752-7163/abc234.
68. Cristiano Lingua, Giuseppe Guida, Iuliana Badiu, Andrea Antonelli and Alberto Macchi. Nasal Cytology as a Biomarker of Inflammatory Respiratory Pathology Type 2: Results of a Cross-Sectional Analysis - Published: September 17, 2021; Volume 3 Issue 10: 40-42. Journal Acta Scientific Otolaryngology
69. Upham J.W.a, bSend mail to Upham J.W.,Le Lievre C.c,Jackson D.J.d, e,Masoli M.f,Wechsler M.E.g,Price D.B.c, h, i,Mansur A.,Detoraki A.,Altraja A.,James A.,Nanzer-Kelly A.,Côté A.,Menzies-Gow A.,Papaioannou A.,Cheffins A.-M.,Bourdin A.,Mahboub B.,Lipworth B.,Celis-Preciado C.A.,Torres-Duque C.,Bucca C.,Porsbjerg C.,Ulrik C.,Corrigan C.,Taube C.,Farah C.,Katelaris C.,Langton D.,Ryan D.,Larenas-Linnemann D.,Zervas E.,Heffler E.,Hoyte F.,Puggioni F.,Christoff G.,Canonica G.W.,Carpagnano G.E.,Guida G.,Katsoulotos G.,Brusselle G.,Rupani H.,Jersmann H.,Clifton I.,Dhariwal J.,Fingleton J.,Duke J.,Rimmer J.,Douglass J.,Fonseca J.,van Boven J.,Corless J.,Harrington J.,Maspero J.,Miguel J.L.,Pipatvech K.,Kenny K.,Chapman K.,Kostikas K.,Lehtimäki L.,Chung L.P.,Heaney L.,Hang L.-W.,Boulet L.-P.,Perez-de-Llano L.,Ricciardi L.,Idrees M.,Milanese M.,Conte M.E.,Costantino M.T.,Siyue M.K.,Fitzgerald M.,Hew M.,Peters M.,Tsai M.-J.,Patel M.,Khan M.H.,Sadatsafavi M.,Al-Ahmad M.,Yacoub M.-R.,De Gennaro M.,Radhakrishna N.,Hanania N.A.,Papadopoulos N.,Lugogo N.,Linaker N.,Crimi N.,Dennison P.,Nair P.,Mitchell P.D.,O'Byrne P.,Pfeffer P.,Kauppi P.,Hughes P.,Middleton P.,Wark P.,Bardin P.,Fu P.-K.,Akuthota P.,Chaudhuri R.,Campos R.,Al-Lehebi R.,Parente R.,Francisco R.,Wenzel S.,Pierachille S.,Pawar S.,Loukides S.,Fowler S.,Mackenzie T.,Brown T.,Lee Tan T.,Björnsdóttir U.,McDonald V.,Lawriwskyj V.,Backer V.,Vasileva V.,Chien Y.-C.,Harrington Z. Defining a Severe Asthma Super-Responder: Findings from a Delphi Process. Journal of Allergy and Clinical Immunology: In Practice2021 DOI 10.1016/j.jaip.2021.06.041
70. Bagnasco D.aSend mail to Bagnasco D.,Paggiaro P.b,Latorre M.b, c,Folli C.a,Testino E.a,Bassi A.a,Milanese M.d,Heffler E.e,Manfredi A.a,Riccio A.M.a,De Ferrari L.a,Blasi F.f, g,Canevari R.F.h, i,Canonica G.W.e,Passalacqua G.a,Guarnieri G.,Patella V.,Maria Pia F.B.,Carpagnano G.E.,Colle A.D.,Scioscia G.,Gerolamo P.,Puggioni F.,Racca F.,Favero E.,Iannacone S.,Savi E.,Montagni M.,Camiciottoli G.,Allegrini C.,Lombardi C.,Spadaro G.,Detoraki C.,Menzella F.,Galeone C.,Ruggiero P.,Yacoub M.R.,Berti A.,Scichilone N.,Durante C.,Costantino M.T.,Roncallo C.,Braschi M.,D'Adda A.,Ridolo E.,Triggiani M.,Parente R.,Maria D.A.,Verrillo M.V.,Rolla G.,Brussino L.,Frazzetto A.V.,Cristina Z.M.,Lilli M.,Crimi N.,Bonavia M.,Corsico A.G.,Grosso A.,Del Giacco S.,Deidda M.,Ricciardi L.,Isola S.,Cicero F.,Amato G.,Vita F.,Spanevello A.,Pignatti P.,Cherubino F.,Visca D.,Massimo Ricciardolo F.L.,Anna Carriero V.M.,Bertolini F.,Santus P.,Barlassina R.,Airoldi A.,Guida G.,Eleonora N.,Aruanno A.,Rizzi A.,Caruso C.,Colantuono S.,Senna G.,Caminati M.,Arcolaci A.,Vianello A.,Bianchi F.C.,Marchi M.R.,Centanni S.,Luraschi S.,Ruggeri S.,Rinaldo R.,Parazzini E.,Calabrese C.,Flora M.,Cosmi L.,Di Pietro L.,Maggi E.,Pini L.,Macchia L.,Di Bona D.,Richeldi L.,Condoluci C.,Fuso L.,Bonini M.,Farsi A.,Carli G.,Montuschi P.,Santini G.,Conte M.E.,Turchet E.,Barbetta C.,Mazza F.,D'Alo S.,Pucci S.,Caiaffa M.F.,Minenna E.,D'Elia L.,Pasculli C.,Viviano V.,Tarsia P.,Rolo J.,Di Proietto M.,Lo Cicero S. Severe asthma: One disease and multiple definitions. World Allergy Organization JournalOpen AccessVolume 14, Issue 11 November 2021 Article number 100606
71. Badiu I, Diena D, Guida G, Ferrando C, Rapezzi D, Besso L.Cutaneous allergic reaction correlates with anti-erythropoietin antibodies in dialysis patient developing pure red cell aplasia. Clin Case Rep. 2022 Apr 4;10(4):e05554. doi: 10.1002/ccr3.5554. eCollection 2022 Apr.
72. Nicola S, Borrelli R, Ridolfi I, Bernardi V, Borrelli P, Guida G, Antonelli A, Albera C, Marengo S, Briozzo A, Norbiato C, Frazzetto AV, Saad M, Lo Sardo L, Bacco B, Gallo Cassarino S, Della Mura S, Bagnasco D, Bucca C, Rolla G, Solidoro P, Brussino L. COPD, but Not Asthma, Is Associated with Worse Outcomes in COVID-19: Real-Life Data from Four Main Centers in Northwest Italy. J Pers Med. 2022 Jul 20;12(7):1184. doi: 10.3390/jpm12071184.
73. Caruso C, Giancaspro R, Guida G, Macchi A, Landi M, Heffler E, Gelardi M.Nasal Cytology: A Easy Diagnostic Tool in Precision Medicine for Inflammation in Epithelial Barrier Damage in the Nose. A Perspective Mini Review. Front Allergy. 2022 Apr 6;3:768408. doi: 10.3389/falgy.2022.768408. eCollection 2022
74. Guida, G; Bagnasco, D ; Carriero, V ; Bertolini, F ; Ricciardolo, FLM ; Nicola, S; Brussino, L ; Nappi, E ; Paoletti, G ; Canonica, GW ; Heffler, E. Critical evaluation of asthma biomarkers in clinical practice. Front Med (Lausanne). 2022 Oct 10;9:969243. doi: 10.3389/fmed.2022.969243. eCollection 2022.
75. Guida G, Carriero V, Bertolini F, Pizzimenti S, Heffler E, Paoletti G, Ricciardolo FLM. Exhaled nitric oxide in asthma: from diagnosis to management.Curr Opin Allergy Clin Immunol. 2023 Feb 1;23(1):29-35. doi: 10.1097/ACI.0000000000000877. Epub 2022 Nov 24.
76. Levra S, Guida G, Sprio AE, Crosa F, Ghio PC, Bertolini F, Carriero V, Albera C, Ricciardolo FLM. Long-Term Safety of Antifibrotic Drugs in IPF: A Real-World Experience.Biomedicines. 2022 Dec 12;10(12):3229. doi: 10.3390/biomedicines10123229.
77. E Riccardi, G Guida, S Pizzimenti, F L M Ricciardolo. The "serial switcher" in severe asthma. Pulmonology. 2023 Jan 28;S2531-0437(23)00004-1. doi: 10.1016/j.pulmoe.2022.12.004. Online ahead of print.

Courses

• ADE - ASTHMA AND COPD: FROM MECHANISMS TO PERSONALIZED THERAPY (SCB0374)
  MedInTO Medicine and Surgery
• Apparato respiratorio (ONC0231B)
  Corso di Laurea in Tecniche di Radiologia Medica, per Immagini e Radioterapia - Cuneo
• Clinica e patologia del torace (canale B) (SME0725)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• I. Infermieristica Clinica dell'Area della Cronicità e della Disabilità - Canale A (MSL0267)
  Corso di laurea in Infermieristica - sede Orbassano Polo Medicina Orbassano e Candiolo
• I. Infermieristica Clinica dell'Area della Cronicità e della Disabilità - Canale B (MSL0267)
  Corso di laurea in Infermieristica - Cuneo
• INFERMIERISTICA CLINICA NELLA CRITICITA' VITALE - D.M. 270/04 (SSP0379)
  Corso di Laurea in Infermieristica - Sede TO4 Ivrea
• Malattie apparato respiratorio - Canale B (MSL0267A)
  Corso di laurea in Infermieristica - Cuneo
• Malattie apparato respiratorio II (canale B) (SME0725G)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Malattie apparato respiratorio I (canale B) (SME0725F)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Malattie apparato respiratorio can.A (MSL0267A)
  Corso di laurea in Infermieristica - sede Orbassano Polo Medicina Orbassano e Candiolo
• Malattie dell'Apparato Respiratorio (MED2953B)
  Corso di laurea in Fisioterapia
• Malattie dell'apparato respiratorio - D.M. 270/04 (SSP0379D)
  Corso di Laurea in Infermieristica - Sede TO4 Ivrea
• SCIENZE INTERDISCIPLINARI E RIABILITAZIONE - nuovo ordinamento (D.M.270/04) (MED2953)
  Corso di laurea in Fisioterapia
• SCIENZE MEDICHE APPLICATE (ONC0231)
  Corso di Laurea in Tecniche di Radiologia Medica, per Immagini e Radioterapia - Cuneo

Research topics

Main fields of research pursued:

-  Relationship between upper airways and bronchial inflammation in rhinitis, sinus and asthmatic pathology with focus on the role of exhaled nitric oxide.

-  Clinical and real-life phenotyping of severe asthma

-  Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss Syndrome): immunophenotyping and genetics

-  Biology and clinical aspects of anaphylaxis, allergic response and allergen immunotherapy.

-  Clinical and immunologic characterization of B-cell Chronic Lymphocytic Leukemia  (B-CLL).

Clinical Reseach Activity:

AOU San Luigi Gonzaga, Orbassano (TO)

CENTRO ASMA GRAVE

Research groups

• Obstructive Pulmonary Disease Group

Activities in agenda

See my calendar

Academic bodies

• Consiglio di Dipartimento - Dipartimento di Scienze Cliniche e Biologiche