MedInTO Medicine and Surgery

Selected research products

1- Di Gregorio E, Romiti C, Di Lorenzo A, Cavallo F, Ferrauto G, Conti L. RGD_PLGA Nanoparticles with Docetaxel: A Route for Improving Drug Efficiency and Reducing Toxicity in Breast Cancer Treatment. Cancers (Basel). 2022 Dec 20;15(1):8. doi: 10.3390/cancers15010008.
2- Yaghobinejad M, Cavallo F, Conti L, Quaglino E. The 21st International Conference on Progress in Vaccination against Cancer (PIVAC-22), September 26-28, 2022, Turin, Italy. Frontiers in bioscience (Landmark edition), 2022, 27(12), pp. 338.
3- Capozza M, Stefania R, Dinatale V, Bitonto V, Conti L, Grange C, Skovronova, R. Terreno, E. A Novel PSMA-Targeted Probe for NIRF-Guided Surgery and Photodynamic Therapy: Synthesis and Preclinical Validation. International Journal of Molecular Sciences, 2022, 23(21), 12878
4- Barutello G, Di Lorenzo A, Gasparetto A, Galiazzi C, Bolli E, Conti L, Cavallo F. Immunotherapy against the Cystine/Glutamate Antiporter xCT Improves the Efficacy of APR-246 in Preclinical Breast Cancer Models. Biomedicines. 2022 Nov 8;10(11):2843. 10.3390/biomedicines10112843 (Co-last).
5- Wang J, Lamolinara A, Conti L, Giangrossi M, Cui L, Morelli MB, Amantini C, Falconi M, Bartolacci C, Andreani C, Orlando F, Provinciali M, Del Pizzo FD, Russo F, Belletti B, Riccardo F, Bolli E, Quaglino E, Cavallo F, Amici A, Iezzi M, Marchini C. HER2-Displaying M13 Bacteriophages induce Therapeutic Immunity against Breast Cancer. Cancers (Basel). 2022 Aug 22;14(16):4054.
3
6- Di Lorenzo A, Bolli E, Ruiu R, Ferrauto G, Di Gregorio E, Avalle L, Savino A, Poggio P, Merighi IF, Riccardo F, Brancaccio M, Quaglino E, Cavallo F, Conti L. Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy. Oncoimmunology. 2022 Jun 15;11(1):2086752.
7- Federica Riccardo, Lidia Tarone, Mariateresa Camerino, Davide Giacobino, Selina Iussich, Giuseppina Barutello, Maddalena Arigoni, Laura Conti, Elisabetta Bolli, Elena Quaglino, Irene Fiore Merighi, Emanuela Morello, Alfredo Dentini, Soldano Ferrone, Paolo Buracco, Federica Cavallo. Antigen mimicry as an effective strategy to induce CSPG4-targeted immunity in dogs with oral melanoma: a veterinary trial. J Immunotherapy of Cancer, 2022, 10(5), e004007.
8- Roberto Ruiu, Antonino Di Lorenzo, Federica Cavallo, Laura Conti. Are Cancer Stem Cells a suitable target for breast cancer immunotherapy? Frontiers in Oncology 2022, Vol. 12. 10.3389/fonc.2022.877384
9- Macagno M, Bandini S, Bolli E, Bello A, Riccardo F, Barutello G, Merighi IF, Forni G, Lamolinara A, Del Pizzo F, Iezzi M, Cavallo F, Conti L, Quaglino E. Role of ADCC, CDC, and CDCC in Vaccine-Mediated Protection against Her2 Mammary Carcinogenesis. Biomedicines, 2022, 10(2), 230. (Corresponding author).
10- Proserpio V, Conti L, Oliviero S. Flow cytometry Single cells for Beginners: Hints and Tips for Approaching the Very First Single-Cell Single cells Technique. Methods Molecular Biology, Vol. 2386, 10.1007/978-1-0716-1771-7. (all the authors contributed equally).
11- Seclì L, L Avalle, Pietro Poggio, G Fragale, C Cannata, Conti L, A Iannucci, G Carrà, C Rubinetto, B Miniscalco, E Hirsch, V Poli, A Morotti, M De Andrea, E Turco, F Cavallo, F Fusella, M Brancaccio. Targeting the extracellular HSP90 co-chaperone Morgana inhibits cancer cell migration and promotes anti-cancer immunity. Cancer Res 2021, in press.
12- Ruiu R, Barutello G, Arigoni M, Riccardo F, Conti L, Peppino G, Annaratone L, Marchiò C, Mengozzi G, Calogero RA, Cavallo F, Quaglino E. Identification of TENM4 as a Novel Cancer Stem Cell-Associated Molecule and Potential Target in Triple Negative Breast Cancer. Cancers 2021, 13(4), 894.
13- Salemme V, G Centonze, F Cavallo, P Defilippi, Conti L. The crosstalk between tumor cells and the immune microenvironment in breast cancer: implications for immunotherapy. Frontiers in Oncology 2021, 11:610303.
14- J Magri, A Gasparetto, L Conti, E Calautti, C Cossu, R Ruiu, G Barutello, Federica Cavallo. The tumor-associated antigen xCT and mutant-p53 as molecular targets for new combinatorial antitumor strategies. Cells 2021
15- A Di Lorenzo, E Bolli, L Tarone, F Cavallo, L Conti. Toll-Like Receptor 2 at the Crossroad between Cancer Cells, the Immune System, and the Microbiota. Int. J. Mol. Sci. 2020, 21(24), 9418.
16- Quaglino E, Cavallo F, Conti L. Cancer stem cell antigens as targets for new combined anti-cancer therapies. The International Journal of Biochemistry & Cell Biology 2020, 105861.
17- A Anemone, L Consolino, L Conti, P Irrera, M Hsu, D Villano, W Dastrù, P Porporato, F Cavallo, D Longo. Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential. British Journal of Cancer 2020 (in press).
18- L Conti, E Bolli, A Di Lorenzo, V Franceschi, F Macchi, F Riccardo, R Ruiu, L Russo; E Quaglino, G Donofrio, F Cavallo. Immunotargeting of the xCT cystine/glutamate antiporter potentiates the efficacy of Her2-targeted immunotherapies in breast cancer. Cancer Immunology Research 8(8), 1039-1053.
19- V Rolih, J Caldeira, E Bolli, A Salameh, L Conti, G Barutello, F Riccardo, J Magri, A Lamolinara, K Parra, P Valenzuela, G Francia, M Iezzi, F Pericle, F Cavallo. Development of a VLP-based Vaccine Displaying an xCT Extracellular Domain for the Treatment of Metastatic Breast Cancer. Cancers 12(6), 1-21, 1492.
20- L Avalle; F Marino; A Camporeale; C Guglielmi; D Viavattene; S Bandini; L Conti; J Cimino; M Forni; C Zanini; A Ghigo; RL Bogorad; F Cavallo; P Provero; V Koteliansky; VPoli. Liver-specific siRNA-mediated Stat3 or C3 knock-down improves the outcome of experimental autoimmune myocarditis. Molecular Therapy - Methods and Clinical Development 2020, 18, 62-72.
21- Riccardo F, Barutello G, Petito A, Tarone L, Conti L, Arigoni M, Musiu C, Izzo S, Volante M, Longo DL, Merighi IF, Papotti M, Cavallo F, Quaglino E. Immunization against ROS1 by DNA Electroporation Impairs K-Ras-Driven Lung Adenocarcinomas. Vaccines 2020, 8(2), 166.
4
22- Quaglino E, Conti L, Cavallo F. Breast cancer stem cell antigens as targets for immunotherapy. Seminars in Immunology 2020, 47, 101386. (all the authors contributed equally).
23- ES Famulari, V Navarro-Tableros, MB Herrera Sanchez, G Bortolussi, M Gai, L Conti, L Silengo, E Tolosano, C Tetta, AF Muro, G Camussi, S Fagoonee, F Altruda. Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice. Scientific Reports 2020; 10(1): 887.
24- Quirico L, Orso F, Esposito CL, Bertone S, Coppo R, Conti L, Catuogno S, Cavallo F, de Franciscis V, Taverna D. Axl-148b chimeric aptamers inhibit breast cancer and melanoma progression. International Journal of Biological Sciences 2020, 16(7), 1238-1251
25- Ruiu R, Tarone L, Rolih V, Barutello G, Bolli E, Riccardo F, Cavallo F, Conti L. Cancer stem cell immunology and immunotherapy: Harnessing the immune system against cancer's source. Progress in Molecular Biology and Translational Science 2019; 164: 119-188.
26- Ruiu R, Rolih V, Bolli E, Barutello G, Riccardo F, Quaglino E, Merighi IF, Pericle F, Donofrio G, Cavallo F, Conti L. Fighting breast cancer stem cells through the immune-targeting of the xCT cystine-glutamate antiporter. Cancer Immunol Immunother 2019;68(1):131-141.
27- G Donofrio, G Tebaldi, S Lanzardo, R Ruiu, E Bolli, A Ballatore, V Rolih, F Macchi, L Conti*, F Cavallo*. Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells. Oncoimmunology 2018, 7:e1494108. (*these authors contributed equally)
28- Witt K, Ligtenberg MA, Conti L, Lanzardo S, Ruiu R, Wallmann T, Tufvesson-Stiller H, Chambers BJ, Rolny C, Lladser A, Lundqvist A, Cavallo F, Kiessling R. Cripto-1 plasmid DNA vaccination targets metastasis and cancer stem cells in murine mammary carcinoma. Cancer Immunol Res 2018, Nov;6(11):1417-1425.
29- G Barutello, V Rolih, M Arigoni, L Tarone, L Conti, E Quaglino, P Buracco, F Cavallo, F Riccardo. Strengths and Weaknesses of Pre-Clinical Models for Human Melanoma Treatment: Dawn of Dogs’ Revolution for Immunotherapy. International Journal of Molecular Sciences 2018, 19:799.
30- E Bolli, JP. O’Rourke, L Conti, S Lanzardo, V Rolih, JM. Christen, G Barutello, M Forni, FPericle, F Cavallo. A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo. Oncoimmunology 2017, 7: e1408746.
31- F Fusella, L Seclì, E Busso, A Krepelova, E Moiso, S Rocca, L Conti, L Annaratone, C Rubinetto, M Mello-Grand, V Singh, G Chiorino, L Silengo, F Altruda, E Turco, A Morotti, S Oliviero, I Castellano, F Cavallo, P Provero, G Tarone, M Brancaccio. The IKK/ NF-κB signalling pathway requires Morgana to drive breast cancer metastasis. Nature Communications 2017, 8:1636.
32- Anemone A, Consolino L, Conti L, Reineri F, Cavallo F, Aime S, Longo DL. In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging. International Journal of Oncology, 2017, 51:498-506.
33- R Tallerico*, L Conti*, S Lanzardo*, R Sottile, C Garofalo, A Wagner, M Johansson, C Cristiani, K K Kärre, E Carbone, F Cavallo NK cells control breast cancer and related cancer stem cell hematological spread. Oncoimmunology 2017, e1284718. (*these authors contributed equally).
34- C Bosia, F Sgrò, L Conti, C Baldassi, D Brusa, F Cavallo, F Di Cunto, E Turco, A Pagnani and R Zecchina. RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells. Genome Biology 2017,18:17-30.
35- S Bandini, M Macagno, A Hysi, S Lanzardo, L Conti, A Bello, F Riccardo, R Ruiu, IF Merighi, G Forni, M Iezzi, E Quaglino and F Cavallo. The non inflammatory role of C1q during Her2/neu driven mammary carcinogenesis. Oncoimmunology 2016, 5:e1253653.
5
36- Longo DL, Stefania R, Callari C, De Rose F, Rolle R, Conti L, Consolino L, Arena F, Aime S. Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy. Adv Healthc Mater. 2016 , Jan;6. doi: 10.1002/adhm.201600550
37- L Conti, S Lanzardo, R Ruiu, M Cadenazzi, F Cavallo, S Aime, S Geninatti Crich. L- Ferritin targets breast cancer stem cells and delivers therapeutic and imaging agents. Oncotarget 2016,;7:66713-66727.
38- CL Gigliotti, RMinelli, R Cavalli, S Occhipinti,·G Barrera, S Pizzimenti, G Cappellano, E Boggio, L Conti,·R Fantozzi, M Giovarelli, F Trotta, U Dianzani, C Dianzani. In Vitro and In Vivo Therapeutic Evaluation of Camptothecin-Encapsulated β-Cyclodextrin Nanosponges in Prostate Cancer . Journal of Biomedical Nanotechnology 2016; 12(1):114-127.
39- S Lanzardo*, L Conti*, R Rooke, R Ruiu, N Accart, E Bolli, M Arigoni, M Macagno, G Barrera, S Pizzimenti, L Aurisicchio, RA Calogero, F Cavallo. Immunotargeting of antigen xCT attenuates stem-like cell behavior and metastatic progression in breast cancer. Cancer Research 2016; 7:62-72. (*these authors contributed equally)
40- S Geninatti Crich, M Cadenazzi, S Lanzardo, L Conti, R Ruiu, D Alberti, F Cavallo, JC Cutrin, S Aime. Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells. Nanoscale 2015; 7:6527-33.
41- M Principe, P Ceruti, NY Shih, M Chattaragada, S Rolla, L Conti, M Bestagno, L Zentilin, SH Yang, P Migliorini, P Cappello, O Burrone, F Novelli. Targeting of surface alpha-Enolase inhibits the invasiveness of pancreatic cancer cells. Oncotarget 2015, 10;6:11098-113
42- Fornari C, Beccuti M, Lanzardo S, Conti L, Balbo G, Cavallo F, Calogero RA, Cordero F. A mathematical-biological joint effort to investigate the tumor-initiating ability of cancer stem cells. Plos One 2014;9(9):e106193.
43- L Conti, R Ruiu, G Barutello, M Macagno, S Bandini, F Cavallo and S Lanzardo. Microenvironment, oncoantigens and anti-tumor vaccination: lessons learned from BALB-neuT mice. Biomed Research International, 2014:534969.
44- M Macagno, S Bandini, L Stramucci, E Quaglino, L Conti, E Balmas, MJ.Smyth, PL Lollini¶, P Musiani, G Forni, M Iezzi, F Cavallo. Multiple roles of perforin in hampering ErbB2 (HER2/neu) carcinogenesis in transgenic male mice. J Immunol 2014, 192:5434-41.
45- C Dianzani, R Minelli, CL Gigliotti, S Occhipinti, M Giovarelli, L Conti, E Boggio, Y Shivakumar, R Pili, R Fantozzi, G Baldanzi, V Malacarne, R Fantozzi, J Yagi, JM Rojo, A Chiocchetti, U Dianzani. B7h triggering inhibits the migration of tumor cell lines. Journal of Immunology 2014;15;192:4921-31.
46- Bolli E, Conti L, Riccardo F, Marchini C, Amici A, Cavallo F, Quaglino E. Second Ascoli Piceno Conference on Gene Vaccination in Cancer (GVC), Ascoli Piceno, Italy, October 9th-11th, 2013. Cancer Immunol Immunotherapy 2014;63:529-33.
47- L Conti, S Lanzardo, M Arigoni, R Antonazzo, E Radaelli, D Cantarella, RA Calogero, F Cavallo. The non-inflammatory role of High mobility group box 1/Toll-like Receptor 2 axis in the self-renewal of mammary cancer stem cells. FASEB Journal, 2013,27:4731-44.
48- R Minelli, S Occhipinti, C L Gigliotti, G Barrera, P Gasco, L Conti, A Chiocchetti, G P Zara, R Fantozzi, M Giovarelli, U Dianzani, C Dianzani. Solid lipid nanoparticles of cholesteryl butyrate inhibit the proliferation of cancer cells in vitro and in vivo models. British Journal of Pharmacology 2013, 170:233-44.
49- Conti L, Lanzardo S, Iezzi M, Montone M, Bolli E, Brioschi C, Maiocchi A, Forni G, and Cavallo F. Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding αvβ3 integrins. Contrast Media and Molecular Imaging, 2013;8:350-60.
6
50- Arigoni M, Barutello G, Riccardo F, Ercole E, Cantarella D, Orso F, Conti L, Lanzardo S, Taverna D, Merighi I, Calogero RA, Cavallo F, Quaglino E. miR-135b coordinates progression of ErbB2-drivern mammary carcinomas through suppression of MID1 and MTCH2. American Journal of Pathology 2013, 182:2058-70.
51- Cordero F, Beccuti M, Fornari C, Lanzardo S , Conti L , Cavallo F , Balbo G and Calogero R. Multi-level model for the investigation of oncoantigendriven vaccination effect. BMC Bioinformatics. 2013;14 Suppl 6:S11
52- Conti L, De Palma R, Rolla S, Boselli D, Rodolico G, Kaur S, Silvennoinen O, Niccolai E, Amedei A, Ivaldi F, Clerico M, Contessa G, Uccelli A, Durelli L, Novelli F. Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2. Journal of Immunology, 2012;188:1011-1018
53- Geninatti S, Cutrin JC, Lanzardo S, Conti L, Kalman FK, Szabo I, Lago NR, Iolascon A, and Aime S. Mn-loaded apoferritin: a highly sensitive MRI imaging probe for the detection and characterization of hepatocarcinoma lesions in a transgenic mouse model. Contrast Media and Molecular Imaging, 2012;7:281-288.
54- Lanzardo S*, Conti L*, Brioschi C, Bartolomeo MP, Arosio D, Belvisi L, Manzoni L, Maiocchi A, Maisano F , Forni G. A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts. Contrast Media and Molecular Imaging, 2011;6:449-458 (*these authors contributed equally)
55- Cordero F, Lanzardo S, Arigoni M, Fornari C, Conti L, Balbo G, Cavallo F, Manini D, Calogero RA. Cancer Stem Cell based adjuvant for oncoantingen-driven vaccination. (2011) 2011 ACM Conference on Bioinformatics, Computational Biology and Biomedicine, BCB 2011, p. 564 - 568.
56- Regis G, Icardi L, Conti L, Chiarle R, Piva R, Giovarelli M, Poli V, Novelli F. IL-6 but not IFN-g triggers apoptosis and inhibits in vivo growth of human malignant T cells upon STAT3 silencing. Leukemia 2009, 23:2102-2108.
57- Durelli L*, Conti L*, Clerico, M, Boselli D, Contessa G, Ripellino P, Ferrero B, Eid P, Novelli F. T Helper 17 Cells Expand in Multiple Sclerosis and are Inhibited by Interferon-β. Annals of Neurology 2009,65:499-509 (*these authors contributed equally).
58- Conti L, Regis G, Longo A, Bernabei P, Chiarle R, Giovarelli M, Novelli F. In The Absence Of Igf-1 Signaling, Ifn-g Suppresses Human Malignant T Cell Growth. Blood 2007, 109:2496-2504.
59- Regis G, Conti L, Boselli D, Novelli F. Ifngammar2 Trafficking Tunes Ifngamma-Stat1 Signaling In T Lymphocytes. Trends Immunol. 2006, 27:96-101.
60- Regis G, Bosticardo M, Conti L, De Angelis S, Boselli D, Tomaino B, Bernabei P, Giovarelli M, Novelli F. Iron Regulates T Lymphocyte Sensitivity To The Ifn-g/Stat1 Signaling Pathway In Vitro And In Vivo. Blood 2005, 105:3214-3221.

Courses

• ADE Immunoterapia dei Tumori (canale D) (SME1019)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• ADE Immunoterapia dei tumori (canale A) (SME1019)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• ADE Immunoterapia dei tumori (canale B) (SME1019)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• ADE Immunoterapia dei tumori (canale C) (SME1019)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Basic Pathology and Immunology (SCB0205)
  MedInTO Medicine and Surgery
• Basic pathology and immunology - Module of Immunology (SCB0205B)
  MedInTO Medicine and Surgery
• IMMUNO-BASED ASSAYS FOR TRANSLATIONAL MEDICINE (BIO0163 Pds 308-BIDD)
  Master Program in Molecular Biotechnology
• I. Patologia e Diagnostica di laboratorio - Canale A (MSL0262)
  Corso di laurea in Infermieristica - sede Orbassano Polo Medicina Orbassano e Candiolo
• I. Patologia e diagnostica di laboratorio - Canale A (MSL0262)
  Corso di laurea in Infermieristica - Cuneo
• Immuno-based assays for translational medicine I (BIO0163A Pds 308-BIDD)
  Master Program in Molecular Biotechnology
• Immunologia - Canale A (MSL0262D)
  Corso di laurea in Infermieristica - Cuneo
• Immunologia can.A (MSL0262D)
  Corso di laurea in Infermieristica - sede Orbassano Polo Medicina Orbassano e Candiolo

Research topics

Gruppi di ricerca

Oncoimmunology Group

Academic bodies

• Consiglio di Dipartimento

Third mission

• Progetto “Sostenere la ricerca nei bambini 0-6”
  Thursday, January 14, 2021