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ADE - CEREBROVASCULAR MALFORMATIONS: PATHOGENETIC MECHANISM AND THERAPEUTIC STRATEGIES

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Ade - Cerebrovascular malformations: pathogenetic mechanism and therapeutic strategies

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Academic year 2019/2020

Course ID
SCB0364
Teacher
Prof. Saverio Francesco Retta (Lecturer)
Year
3rd year
Teaching period
Second semester
Type
Elective
Credits/Recognition
1
Course disciplinary sector (SSD)
BIO/13 - biologia applicata
MED/03 - genetica medica
MED/04 - patologia generale
MED/26 - neurologia
MED/27 - neurochirurgia
MED/37 - neuroradiologia
Delivery
Lecture
Language
English
Attendance
Mandatory
Type of examination
Oral
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Sommario del corso

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Course objectives

-

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Results of learning outcomes

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Course delivery

Webex lectures/seminars

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Learning assessment methods

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Program

Elective Didactic Activity (EDA/ADE)
Cerebrovascular malformations: pathogenic mechanisms and therapeutic strategies

27/04/2020

9:30-11:00 and 12:00-13:00 Prof. S. Francesco Retta, Applied Biology (University of Torino) Genetic and molecular mechanisms in the pathogenesis of cerebrovascular diseases: introduction, experimental models and fundamental discoveries

11:00-12:00  Prof. Marco Fontanella, Neurosurgery (University of Brescia, Italy)
Clinical and neurosurgical features of Cerebral Cavernous Malformation (CCM) disease

28/04/2020

10:00-11:00  Prof. Chris Sobey, Cardiovascular Biology & Disease Research (La Trobe University and Monash University, Melbourne, Australia)
Targeting inflammation-induced injury in stroke

11:30-13:00  Dr. Raffaella Mastrocola, General Pathology (University of Torino)
Gut-brain axis and microbiome in the pathogenesis of cerebrovascular diseases

17:00-18:00  Dr. Jun Zhang, Molecular and Translational Medicine (Texas Tech University Health Science Center, USA)
KRIT1-ICAP1 interaction provides insights into CCM disease pathogenesis

29/04/2020

09:00-11:00  Prof. Giovanni Battista Ferrero, Clinical Genetics (University of Torino)
Next-Generation Sequencing (NGS) and multiple genetic test (NGS panel): new moleculardiagnostic technique of cerebrovascular malformations of genetic origin

11:15-12:15  Dr. Valerio Benedetti, Medical Genetics (University of Torino)
Genetic basis of Cerebral Cavernous Malformation and genetic modifiers of disease severity

12:30-13:30  Dr. Andrea Perrelli, Applied Biology (University of Torino)
Cerebrovascular Malformations: from pathogenetic mechanisms to targeted therapeutic approaches

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Suggested textbooks and readings

  1. Kim AH, Perrelli A, Ragni A, Retta F, De Silva TM, Sobey GC, Retta SF*. (2020). Vitamin D Deficiency and the Risk of Cerebrovascular Disease. Antioxidants (Basel). 2020 Apr 17; 9(4), pii: E327; doi:10.3390/antiox9040327.
  2. Antognelli C, Perrelli A, Armeni T, Nicola Talesa V, Retta SF*. (2020). Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations. Antioxidants (Basel). 2020 Feb 1; 9(2). pii: E124. doi: 10.3390/antiox9020124.
  3. Vieceli Dalla Sega F, Mastrocola R, Aquila G, Fortini F, Fornelli C, Zotta A, Cento AS, Perrelli A, Boda E, Pannuti A, Marchi S, Pinton P, Ferrari R, Rizzo P, Retta SF*. (2019). KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. Int J Mol Sci. 2019 Oct 5; pii: E4930. doi:c10.3390/ijms20194930.
  4. Cianfruglia L, Perrelli A, Fornelli C, Magini A, Gorbi S, Salzano AM, Antognelli C, Retta F, Benedetti V, Cassoni P, Emiliani C, Principato G, Scaloni A, Armeni T, Retta SF*. (2019). KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins. Antioxidants (Basel). 2019 Jan 17;8(1):1-28.
  5. De Luca E, Pedone D, Moglianetti M, Pulcini D, Perrelli A, Retta SF* & Pompa PP (2018). Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation. ACS Omega, 2018 Nov 30;3(11):15389-15398.
  6. Perrelli A, Goitre L, Salzano AM, Moglia A, Scaloni A, and Retta SF*. (2018). Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases. Oxidative Medicine and Cellular Longevity 2018, 6015351.
  7. Antognelli C, Trapani E, Delle Monache S, Perrelli A, Daga M, Pizzimenti S, Barrera G, Cassoni P, Angelucci A, Trabalzini L, Talesa VN, Goitre L, Retta SF*. (2018). KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease. Free Radical Biology and Medicine 2018 Feb 1; 115:202-218. Epub 2017 Nov 21.
  8. Antognelli C, Trapani E, Delle Monache S, Perrelli A, Fornelli C, Retta F, Cassoni P, Talesa VN, Retta SF*. (2017). Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function. Data Brief. 2017 Dec 13; 16:929-938.
  9. Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF* & Glading AJ. (2017). Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium. Scientific Reports, 2017 Aug 15; 7(1):8296.
  10. Retta SF* and Glading AJ. (2016). Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin. International Journal of Biochemistry & Cell Biolology. 2016 Dec; 81(Pt B):254-270.
  11. Marchi S, Trapani E, Corricelli M, Goitre L, Pinton P, Retta SF*. (2016). Beyond Multiple Mechanisms and a Unique Drug: Defective Autophagy as Pivotal Player in Cerebral Cavernous Malformation Pathogenesis and Implications for Targeted Therapies. Rare Diseases, 2016 Jan 25; 4:1, e1142640.
  12. Marchi S, Retta SF*, Pinton P. (2016). Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view. Autophagy, 2016 Feb; 12(2):424-5.
  13. Moglianetti M, De Luca E, Pedone D, Marotta R, Catelani T, Sartori B, Amenitsch H, Retta SF, Pompa PP. (2016). Platinum nanozymes recover cellular ROS homeostasis in oxidative stress-mediated disease model. Nanoscale, 2016 Feb 14; 8(6):3739-52.
  14. Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A., Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF*. (2016). Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radical Biology and Medicine, 2016 Jan 19; 92:100-109.
  15. Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF*, Pinton P. (2015). Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Molecular Medicine, 2015. 7(11):1403-1417.
  16. Trapani E, Retta SF*. (2015). Cerebral cavernous malformation (CCM) disease: from monogenic forms to genetic susceptibility factors. Journal of Neurosurgical Sciences, 2015 Sep; 59(3):201-9.
  17. Gibson C., Zhu W., Davis C.T., Bowman-Kirigin J.A., Chan A.C., Ling J., Walker A.E., Goitre L., Delle Monache S., Retta S.F., Shiu Y-T E., Grossmann A.H., Thomas K.R., Donato A.J., Lesniewski L.A., Whitehead K.J., Li D.J. (2015) Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation. Circulation, 2015; 131(3):289-99.
  18. Fontanella MM, Panciani PP, Spena G, Roca E, Migliorati K, Ambrosi C, Sturiale CL, Retta SF (2015) Professional athletes and cerebral cavernomas: an obstacle to overcome. Journal of Sports Medicine and Physical Fitness, 2015 Sep; 55(9):1046-7.
  19. Goitre L, De Luca E, Braggion S, Trapani E, Guglielmotto M, Biasi F, Forni M, Moglia A, Trabalzini L, Retta SF*. (2014) KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun. Free Radical Biology and Medicine, 2014 Mar; 68:134-47.
  20. Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, Ferrarini L, Orsenigo F, Papa E, Boulday G, Tournier-Lasserve E, Chapon F, Richichi C, Retta SF, Lampugnani MG, Dejana E. (2013) EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature,2013; 498(7455):492-6.
  21. Bacigaluppi S, Retta S.F., Pileggi S, Fontanella M, Goitre L, Tassi L, La Camera A, Citterio A, Patrosso MC, Tredici G, Penco S. (2013) Genetic and cellular basis of Cerebral Cavernous Malformations: implications for clinical management. Clinical Genetics, 2013; 83(1):7-14.
  22. D’Angelo R., Marini V., Rinaldi C., Origone P., Dorcaratto A., Avolio M., Goitre L., Forni M., Capra V., Alataci C., Mareni C., Garrè C., Bramanti P., Sidoti A., Retta S.F.*, Amato A. (2011). Mutation Analysis of CCM1, CCM2 and CCM3 Genes in a Cohort of Italian Patients with Cerebral Cavernous Malformation. Brain Pathology, 2011; 21(2): 215–224.
  23. Goitre L., Balzac F., Degani S., Degan P., Marchi S., Pinton P., Retta S.F.* (2010). KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species. PLoS One, 2010; 5(7):e11786.
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Class schedule

DaysTimeClassroom
Monday9:00 - 13:00
Tuesday9:00 - 13:00
Wednesday9:00 - 13:00

Lessons: dal 27/04/2020 to 29/04/2020

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Last update: 11/05/2020 09:55
Location: https://www.medinto.unito.it/robots.html
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