MedInTO Medicine and Surgery

Nephrology, rheumatology and clinical immunology

Nephrology, rheumatology and clinical immunology

Academic year 2020/2021

Sommario del corso

• Course objectives
• Results of learning outcomes
• Course delivery
• Learning assessment methods
• Program
• Suggested textbooks and readings
• Notes
• Course modules
• Teaching tools

Course objectives

This course will provide a foundation in knowledge and skills necessary for medical students to recognize the most important medical problems and to construct clinical reasoning models in the field of nephrology, rheumatology and clinical immunology.
Upon successful completion of this course, students will be able to demonstrate the knowledge, attitudes and skills needed to indentify and  provide basic care for patients with nephrology, rheumatologic and immunologic diseases.
Students will be able to formulate a differential diagnosis, assessment and a prioritized plan for the standardized patient.

Results of learning outcomes

Demonstrate knowledge, clinical and technical skills and decision-making capabilities pertinent to the management of patients with medical problems in the field of nephrology, rheumatology and clinical immunology.

Course delivery

Online via Webex.

Learning assessment methods

The exam test covers all the disciplines included in the course and the final score proportionally takes into account results of each module.

EXAMINATION ARRANGEMENTS: written and oral.

• WRITTEN:
  • MED/05 - Clinical Pathology;
  • MED/09 - Internal Medicine;
  • MED/15 – Rheumatology.

• ORAL:
  • MED/14 – Nephrology.

Program

Nephrology

• Assessment of Glomerular Filtration Rate.
• Urinalysis.
• Disorders of Sodium and Potassium Metabolism.
• Approach to Acid-Base Disorders.
• Glomerular Clinicopathologic Syndromes.
• Minimal Change Disease.
• Focal Segmental Glomerulosclerosis.
• Membranous Nephropathy.
• Immunoglobulin A Nephropathy.
• Goodpasture Syndrome and Other Antiglomerular Basement Membrane Diseases.
• Postinfectious Glomerulonephritis.
• Renal involvement in systemic vasculitis (granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis).
• Henoch-Schönlein Purpura Nephritis (IgA vasculitis).
• Lupus Nephritis.
• Pathogenesis, Pathophysiology, and Treatment of Diabetic Nephropathy.
• Dysproteinemias related disorders.
• Amyloidosis.
• Thrombotic Microangiopathies and aPL Nephropathy.
• The Kidney in Cancers.
• Acute Kidney Injury.
• Polycystic and Other Cystic Kidney Diseases and Nephronophthisis and Medullary Cystic Kidney Disease.
• Alport Syndrome and Related Disorders.
• Fabry Disease.
• Chronic Tubulointerstitial Disease.
• Nephrolithiasis.
• Urinary Tract Infection and Pyelonephritis.
• Pregnancy in immunomediated and kidney diseases.
• Chronic Kidney Disease and its Therapy.
• Kidney Replacement Therapies: Dialysis and Transplantation.

Rheumatology

• Introductory Aspects of RMDs.
• Inflammatory Arthropathies.
• Rheumatoid arthritis.
• Spondyloarthritis.
• The concept of Spondyloarthritis.
• Ankylosing Spondylitis.
• Psoriatic arthritis.
• Enteropathic arthritis.
• Reactive arthritis.
• Undifferentiated Spondyloarthritis.
• Autoinflammatory Syndromes.
• Familial Mediterrannean Fever.
• Adult Still Disease.
• IGG4-related Disease.
• Connective Tissue Diseases:
  • Systemic Lupus Erythematosus;
  • Antiphospholipid Syndrome;
  • Systemic Sclerosis;
  • Sjögren Syndrome;
  • Overlap Syndromes;
  • Mixed Connective Tissue Disease;
  • Undifferentiated Connective Tissue Disease.
• Polymyositis and Dermatomyositis.
• Polymyalgia Rheumatica and Giant Cell Arteritis.
• Vasculitis.
• Giant Cell Arteritis.
• Takayasu’s arteritis.
• Kawasaki Disease.
• Polyarteritis nodosa.
• ANCA-vasculitis.
• Behçet Disease.

Clinical Immunology

• Allergic diseases (including Extrinsic allergic alveolitis).
• Immunodeficiencies.
• Complements defects.
• Phagocyte deficiencies and basophils/eosinophils diseases.
• Sarcoidosis.
• Idiopathic lung fibrosis.
• Oncoimmunology.
• Drug hypersensitivity.
• Glucocorticoids, immunoglobulin-therapy and immunomodulating drugs.

Proteomics and Genomics

• Laboratory assessment of immune-mediated diseases:
  • Principles of EIA and IF techniques;
  • ANA, anti DNA, ENA, ANCA, Ra Test, Anti-CCP, cryoglobulin detection, Antiphospholipid antibody detection.
• Big data analyses.
• Principles of NGS procedures.
• Genomics and phenotypes.
• Proteomic approches to diagnosis and therapy.
• Mosaics in Autoimmunity (Yehuda Shoenfeld lectures).
• Immune-neurological diseases.
• ASIA syndrome and Sylicosis.
• Sclerodermic disorders.

• Clinical Immunology - Principles and Practice, 5th Edition – 2019 (available for UNITO student via BiblioPASS)
• Harrison – Principles of Internal Medicine
• EULAR Textbook of Rheumatology (www.eular.org)
• Laposata's Laboratory Medicine: diagnosis of distaste in Clinical laboratory. Ma Graw Hill Education (available for UNITO student via BiblioPASS)
• Immunoassay _ P Diamondis TK Christopulos _ Science Direct( available for UNITO student via BiblioPASS)
• CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e Edgar V. Lerma, Mitchell H. Rosner, Mark A. Perazella (available for UNITO student via BiblioPASS)
• Oxford Textbook of Clinical Nephrology Fourth Edition Three-Volume Pack Chief Editor Neil N. Turner, Edited by Neil N. Turner, Norbert Lameire, David J. Goldsmith, Christopher G. Winearls, Jonathan Himmelfarb, and Giuseppe Remuzz

Class schedule

Note

MED/05 - Clinical Pathology (1 CFU)
MED/09 - Internal Medicine (1 CFU)
MED/14 – Nephrology (3 CFU)
MED/15 – Rheumatology (1 CFU)

Professors are available upon mail contact.

Moduli didattici

• Nephrology, rheumatology and clinical immunology - Module of Clinical Immunology (SCB0220C)
• Nephrology, rheumatology and clinical immunology - Module of Nephrology (SCB0220A)
• Nephrology, rheumatology and clinical immunology - Module of Proteomics and Genomics (SCB0220D)
• Nephrology, rheumatology and clinical immunology - Module of Rheumatology (SCB0220B)

• Teaching materials
• Exams and finals
• Go to Moodle
• Visit the forums